Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.
Role of magnetic resonance spectroscopy in cerebral glutathione quantification for youth mental health: A systematic review.
复制标题
磁共振波谱在青少年心理健康脑谷胱甘肽定量中的作用：系统评价。
DOI：
10.1111/eip.12833
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发表时间：
2020
影响因子：
2
通讯作者：
Fisher E
中科院分区：
文献类型：
--
作者：
Fisher E
氧化应激与许多精神疾病密切相关，这导致了新的干预措施的发展，试图扰乱这一病理。谷胱甘肽是大脑中的主要抗氧化剂，在清除自由基和其他活性氧物种方面发挥着基础性作用，一直受到人们的极大关注。在体内测量大脑中的谷胱甘肽浓度可以提供有关氧化还原状态和氧化应激发展潜力的信息。谷胱甘肽也可能是评估治疗反应的一个标记物。方法本文系统地回顾了在不同心理健康状况下评估谷胱甘肽浓度(用磁共振波谱测量)的研究。结果显示精神障碍患者脑内谷胱甘肽浓度改变的证据有限；最好的证据表明，谷胱甘肽在抑郁症中减少，但在双相情感障碍中没有改变。结论对现有研究中可测量的最小效应大小的分析表明，需要更多的参与者来测量细微但可能重要的差异，并推动该领域的发展。
AimOxidative stress is strongly implicated in many psychiatric disorders, which has resulted in the development of new interventions to attempt to perturb this pathology. A great deal of attention has been paid to glutathione, which is the brain's dominant antioxidant and plays a fundamental role in removing free radicals and other reactive oxygen species. Measurement of glutathione concentration in the brain in vivo can provide information on redox status and potential for oxidative stress to develop. Glutathione might also represent a marker to assess treatment response.MethodsThis paper systematically reviews studies that assess glutathione concentration (measured using magnetic resonance spectroscopy) in various mental health conditions.ResultsThere is limited evidence showing altered brain glutathione concentration in mental disorders; the best evidence suggests glutathione is decreased in depression, but is not altered in bipolar disorder. The review then outlines the various methodological options for acquiring glutathione data using spectroscopy.ConclusionsAnalysis of the minimum effect size measurable in existing studies indicates that increased number of participants is required to measure subtle but possibly important differences and move the field forward.