USE OF HIGH-DOSE NALOXONE IN ACUTE STROKE - POSSIBLE SIDE-EFFECTS
USE OF HIGH-DOSE NALOXONE IN ACUTE STROKE - POSSIBLE SIDE-EFFECTS
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DOI：
10.1097/00003246-198908000-00009
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发表时间：
1989-08-01
影响因子：
8.8
通讯作者：
MARLER, J
中科院分区：
文献类型：
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作者：
BARSAN, WG;OLINGER, CP;MARLER, J
高剂量纳洛酮对人体的影响尚未得到广泛研究。我们用高剂量纳洛酮治疗了 36 名急性缺血性脑梗塞患者，以评估潜在的疗效和毒性。所有患者均接受160 mg/m 2 (4 mg/kg)负荷剂量治疗，随后接受80 mg/m 2 h (2 mg/kg h)±24 h治疗。尽管四名患者确实出现了临床上显着的变化，但负荷剂量或输注引起的组平均动脉压、呼吸频率或心率没有统计学上显着的变化。 23 名患者出现可能与纳洛酮相关的不良反应。其中最常见的是恶心（n = 20）、心动过缓和/或低血压（n = 3）、肌阵挛（n = 1）和高血压（n = 1）。七名患者因可能的不良反应而停用纳洛酮。当需要时停止纳洛酮和/或药物治疗后，所有不良反应都会减轻。纳洛酮治疗没有造成死亡。大多数患有急性脑梗塞的老年患者似乎对高剂量纳洛酮具有良好的耐受性。
The effects of high dose naloxone in humans have not been studied extensively. We treated 36 patients who had acute ischemic cerebral infarction with high doses of naloxone to evaluate potential efficacy and toxicity. All patients were treated with a 160-mg/m 2 (4-mg/kg) loading dose followed by 80 mg/m 2 h (2 mg/kg h)±24 h. There were no statistically significant changes in group mean arterial pressure, respiratory rate, or heart rate in response to the loading dose or infusion, although clinically significant changes did occur in four patients. Twenty-three patients had adverse reactions possibly related to naloxone. the most common of which were nausea (n= 20), bradycardia and/or hypotension (n= 3), myoclonus (n= 1), and hypertension (n= 1). Seven patients had naloxone discontinued for possible adverse reactions. All adverse reactions abated with discontinuation of naloxone and/or phar-macologic therapy when indicated. No deaths were attributable to naloxone treatment. High dose naloxone appears to be well tolerated in the majority of elderly patients with acute cerebral infarction.