Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques.
Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques.
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DOI：
10.1016/j.neuron.2015.08.018
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发表时间：
2015-09-02
期刊：
影响因子：
16.2
通讯作者：
Rushworth MF
中科院分区：
文献类型：
--
作者：
Chau BK;Sallet J;Papageorgiou GK;Noonan MP;Bell AH;Walton ME;Rushworth MF
最近的研究对眶额皮质和杏仁核调节灵活的奖励引导行为的观点提出了挑战。我们训练猕猴在fMRI会话期间执行物体识别逆转任务，并确定了一个外侧OFC （lOFC）区域，该区域的活动预测适应性的赢-留/输-移行为。杏仁核和lOFC的活动在lose-shift试验中耦合更强。然而，lofc -杏仁核耦合也受到奖励信息相关性的调节，其作用与建立奖励信用分配的方式一致。信号的日常波动和信号耦合与性能的日常波动相关。第二个实验证实了在概率学习任务中，lOFC中存在适应性停留/转移行为信号，并反映了杏仁核中不相关奖励的存在。我们的数据表明OFC和杏仁核各自对灵活行为和信用分配做出了独特的贡献。眶额皮层活动的变化与学习的变化相关。杏仁核携带有关无关奖励的信息。杏仁核-眶额皮层相互作用强调相关的非无关奖励。Chau等人发现了后外侧OFC （lOFC）区域，该区域的活动预测适应性的赢-留/输-移行为。杏仁核的活动只能预测输掉的行为，但它携带着无关奖励的信息。lofc -杏仁核的连通性受到奖励信息相关性的动态调节。
Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an object discrimination reversal task during fMRI sessions and identified a lateral OFC (lOFC) region in which activity predicted adaptive win-stay/lose-shift behavior. Amygdala and lOFC activity was more strongly coupled on lose-shift trials. However, lOFC-amygdala coupling was also modulated by the relevance of reward information in a manner consistent with a role in establishing how credit for reward should be assigned. Day-to-day fluctuations in signals and signal coupling were correlated with day-to-day fluctuation in performance. A second experiment confirmed the existence of signals for adaptive stay/shift behavior in lOFC and reflecting irrelevant reward in the amygdala in a probabilistic learning task. Our data demonstrate that OFC and amygdala each make unique contributions to flexible behavior and credit assignment. Orbitofrontal cortex determines future behavior on the basis of reward feedback Variation in orbitofrontal cortex activity is correlated with variation in learning Amygdala carries information about irrelevant reward Amygdala-orbitofrontal interactions emphasize relevant not irrelevant reward Chau et al. identify a posterior lateral OFC (lOFC) region in which activity predicts adaptive win-stay/lose-shift behavior. Amygdala activity predicts only lose-shift behavior but carries information about irrelevant rewards. lOFC-amygdala connectivity is modulated dynamically by the relevance of reward information.