Effects of rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats
Effects of rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats
复制标题
山羊下颌骨牵张成骨过程中快速牵张速率对新骨形成的影响
DOI：
10.1016/j.injury.2008.09.011
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发表时间：
2009-08-01
影响因子：
2.5
通讯作者：
Wu, Ling
中科院分区：
文献类型：
--
作者：
Long, Jie;Tang, Wei;Wu, Ling
目的：牵引成骨通常需要沿着治疗期，这可能导致骨和软组织感染以及相当大的患者不适。由于颅面骨的独特特性，包括与长骨相比的丰富的血液供应和快速的骨愈合，在颅面牵张成骨中使用快速牵张速率以缩短牵张时间是可能的。然而，在颅面畸形的治疗中使用快速牵引率的效果目前尚不清楚。本研究的目的是探讨快速牵张速率对山羊下颌骨牵张成骨过程中新骨形成的影响。方法：将16只山羊随机分为4组，每组4只。在A、B和C组中，每只山羊的右下颌骨分别以0.8 mm/d、1.6 mm/d和2.0 mm/d的速率牵张; D组为对照组，不进行牵张。结果：A组骨密度均值显著高于其他各组（p < 0.05），C组骨密度均值显著低于其他各组（p <0.05）。A、B和C组的平均曲线斜率、峰值应力、弯曲模量和失效能量值均显著低于对照组（p < 0.05）。随着牵张速率的增加，曲线斜率和应力峰值逐渐下降（p < 0.05）。结论：在下颌骨牵张成骨过程中，尽管颅面骨血供丰富，但采用快速牵张速率可能会对新骨质量产生不利影响。(C)2008爱思唯尔有限公司保留所有权利。
Objective: Distraction osteogenesis typically requires along treatment period, which can lead to bone and soft-tissue infection and considerable patient discomfort. Use of a rapid distraction rate in craniofacial distraction osteogenesis to shorten the distraction period is possible owing to the unique characteristics of craniofacial bones, including an abundant blood supply and rapid bone healing compared with long bones. The effects Of using a rapid distraction rate in the treatment of craniofacial deformities are currently unclear, however. The objective of this study was to investigate the effects of a rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats.Methods: Sixteen goats were randomly divided into four groups consisting of four goats each. In Groups A, B, and C, the right mandible of each goat was distracted at a rate of 0.8 mm/d, 1.6 mm/d, and 2.0 mm/d, respectively; Group D was the control group and did not undergo distraction. Six weeks after the conclusion of distraction, bone densitometry and three-point bending testing were performed in all groups.Results: The mean bone density value of goats in Group A was significantly higher than those of all the other groups (p < 0.05), and the mean bone density value of goats in Group C was significantly lower than those of all the other groups (p < 0.05). The mean Curve slope, peak stress, bending modulus, and energy to failure values of Groups A, B, and C were all significantly lower than those of the control group (p < 0.05). As the distraction rate increased, the curve slope and peak stress values gradually declined (p < 0.05).Conclusions: Use of a rapid distraction rate in mandibular distraction osteogenesis may have detrimental effects on the quality of new bone, despite the abundant blood supply of cranicifacial bones. (C) 2008 Elsevier Ltd. All rights reserved.