Abnormal N-acetylaspartate in hippocampus and anterior, cingulate in posttraumatic stress disorder
Abnormal N-acetylaspartate in hippocampus and anterior, cingulate in posttraumatic stress disorder
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DOI：
10.1016/j.pscychresns.2007.04.011
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发表时间：
2008-02-28
影响因子：
2.3
通讯作者：
Weiner, Michael W.
中科院分区：
文献类型：
--
作者：
Schuff, Norbert;Neylan, Thomas C.;Weiner, Michael W.
磁共振波谱成像（MRSI）的研究表明，海马异常的创伤后应激障碍（PTSD），而在海马体积赤字的结果，如磁共振成像（MRI）显示，一直不一致。PTSD的合并症，特别是酗酒，可能导致了这种不一致。目的是确定海马和其他脑区的体积和代谢异常是否存在于PTSD中，而与酒精滥用无关。四组受试者，PTSD患者（n=28）和无（n=27）酒精滥用和PTSD阴性的受试者（n=23）和无（n=26）酒精滥用，被纳入这项观察性MRI和MRSI研究的结构和代谢脑异常的PTSD。创伤后应激障碍与减少N-乙酰天冬氨酸（NAA）在左侧和右侧海马，虽然只有当正常化的肌酸水平在没有显着的海马体积减少。此外，PTSD与右前扣带回皮质NAA减少有关，与肌酸无关。NAA似乎是PTSD中神经元异常的一个比脑体积更敏感的标志物。PTSD患者前扣带皮层的改变与恐惧条件反射和消退有关。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Magnetic resonance spectroscopic imaging (MRSI) studies suggest hippocampal abnormalities in posttraumatic stress disorder (PTSD), whereas findings of volume deficits in the hippocampus, as revealed with magnetic resonance imaging (MRI), have been inconsistent. Co-morbidities of PTSD, notably alcohol abuse, may have contributed to the inconsistency. The objective was to determine whether volumetrie and metabolic abnormalities in the hippocampus and otherbrain regions are present in PTSD, independent of alcohol abuse. Four groups of subjects, PTSD patients with (n=28) and without (n=27) alcohol abuse and subjects negative for PTSD with (n=23) and without (n=26) alcohol abuse, were enrolled in this observational MRI and MRSI study of structural and metabolic brain abnormalities in PTSD. PTSD was associated with reduced N-acetylaspartate (NAA) in both the left and right hippocampus, though only when normalized to creatine levels in the absence of significant hippocampal volume reduction. Furthermore, PTSD was associated with reduced NAA in the right anterior cingulate cortex regardless of creatine. NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulate cortex in PTSD has implications for fear conditioning and extinction. (c) 2007 Elsevier Ireland Ltd. All rights reserved.