Neurotropic viral infections leading to epilepsy: focus on Theiler's murine encephalomyelitis virus.
Neurotropic viral infections leading to epilepsy: focus on Theiler's murine encephalomyelitis virus.
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DOI：
10.2217/fvl.11.107
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发表时间：
2011-11
期刊：
影响因子：
3.1
通讯作者：
Fujinami RS
中科院分区：
文献类型：
--
作者：
Libbey JE;Fujinami RS
嗜神经病毒引起病毒性脑炎，并与发作/癫痫的发展有关。本文描述了第一个感染驱动的癫痫动物模型，即Theiler小鼠脑脊髓炎病毒诱导的癫痫模型。C57BL/6小鼠脑内感染泰勒氏小鼠脑脊髓炎病毒可引起急性癫痫发作，并可恢复。然而，一旦病毒被清除，经历急性癫痫发作的动物中有很大一部分后来发展为癫痫。对病毒感染的先天免疫反应的组成部分，包括IL-6和补体成分3，与急性癫痫发作的发展有关。多种机制，包括神经元细胞破坏和细胞因子激活，在急性癫痫发作的发展中发挥作用。未来针对先天免疫反应的研究将为癫痫发作/癫痫带来新的治疗方法。
Neurotropic viruses cause viral encephalitis and are associated with the development of seizures/epilepsy. The first infection-driven animal model for epilepsy, the Theiler’s murine encephalomyelitis virus-induced seizure model is described herein. Intracerebral infection of C57BL/6 mice with Theiler’s murine encephalomyelitis virus induces acute seizures from which the animals recover. However, once the virus is cleared, a significant portion of the animals that experienced acute seizures later develop epilepsy. Components of the innate immune response to viral infection, including IL-6 and complement component 3, have been implicated in the development of acute seizures. Multiple mechanisms, including neuronal cell destruction and cytokine activation, play a role in the development of acute seizures. Future studies targeting the innate immune response will lead to new therapies for seizures/epilepsy.