Acute Renal Failure Due to Leukemic Cell Infiltration Followed by Relapse at Multiple Extramedullary Sites in a Child with Acute Lymphoblastic Leukemia
Acute Renal Failure Due to Leukemic Cell Infiltration Followed by Relapse at Multiple Extramedullary Sites in a Child with Acute Lymphoblastic Leukemia
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DOI：
10.1080/10428190310001593148
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发表时间：
2004-04
影响因子：
2.6
通讯作者：
A. Sato;M. Imaizumi;S. Chikaoka;H. Niizuma;Y. Hoshi;J. Takeyama;Kunihiro Fujii;Toshiyuki Nishio;Mika Watanabe;C. Maesawa;Y. Hayashi;K. Iinuma
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文献类型：
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作者：
A. Sato;M. Imaizumi;S. Chikaoka;H. Niizuma;Y. Hoshi;J. Takeyama;Kunihiro Fujii;Toshiyuki Nishio;Mika Watanabe;C. Maesawa;Y. Hayashi;K. Iinuma
在儿童急性淋巴细胞性白血病(ALL)中，由于白血病渗入肾脏而导致的急性肾功能衰竭是罕见的。我们在此报告一位五岁男童，发病时因白血病渗入而出现急性肾功能衰竭。强的松龙联合血液透析治疗有效。但他在中枢神经系统、睾丸和胰腺等髓外部位出现持续性或反复复发，提示该患者的白血病细胞可能与髓外器官有很高的亲和力。根据以前的报道和这位患者的经验，所有肾脏受累的儿童可能都需要加强治疗。
Acute renal failure due to leukemic infiltration into the kidney is rare in childhood acute lymphoblastic leukemia (ALL). We report here a five year-old boy with ALL who presented acute renal failure caused by leukemic infiltration at onset. Treatment with predonisolone and hemodialysis was effective. However, he showed persistent or repeated relapses at extramedullary sites, such as central nervous system, testis, and pancreas, suggesting that leukemic cells of this patient may have had a high affinity to extramedullary organs. On the basis of previous reports and the experience of this patient, intensive treatment may be needed in ALL children with renal involvement.