Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer.
Factors influencing the uptake of 18F-fluoroestradiol in patients with estrogen receptor positive breast cancer.
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DOI：
10.1016/j.nucmedbio.2011.03.002
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发表时间：
2011-10
影响因子：
3.1
通讯作者：
Mankoff DA
中科院分区：
文献类型：
--
作者：
Peterson LM;Kurland BF;Link JM;Schubert EK;Stekhova S;Linden HM;Mankoff DA
18F-Fluoroestradiol (FES) PET imaging provides a non-invasive method to measure estrogen receptor (ER) expression in tumors. Assessment of factors that could affect the quantitative level of FES uptake is important as part of the validation of FES PET for evaluating regional ER expression in breast cancer. This study examines FES uptake in tumors from 312 FES PET scans (239 patients) with documented ER+ primary breast cancer. FES uptake was compared to clinical and laboratory data; treatment prior to or at time of scan; and properties of FES and its metabolism and transport. Linear mixed models were used to explore univariate, threshold-based, and multivariate associations. Sex-hormone binding globulin (SHBG) was inversely associated with FES SUV. Average FES uptake did not differ by levels of plasma estradiol, age, or rate of FES metabolism. FES tumor uptake was greater for patients with a higher body mass index (BMI), but this effect did not persist when SUV was corrected for lean body mass (LBM). In multivariate analysis, only plasma SHBG binding was an independent predictor of LBM-adjusted FES SUV. Calculation of FES SUV, possibly adjusted for lean body mass, should be sufficient to assess FES uptake for the purpose of inferring ER expression. Pre-menopausal estradiol levels do not appear to interfere with FES uptake. The availability and binding properties of SHBG influence FES uptake and should be measured. Specific activity did not have a clear influence on FES uptake, except perhaps at higher injected mass/kg. These results suggest that FES imaging protocols may be simplified without sacrificing the validity of the results.
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影响因子：
3.1
作者：
Jonson, SD;Bonasera, TA;Welch, MJ
通讯作者：
Welch, MJ
影响因子：
3.1
作者：
Lim, JL;Zheng, L;Tewson, TJ
通讯作者：
Tewson, TJ
影响因子：
3.1
作者：
KATZENELLENBOGEN, JA;MATHIAS, CJ;WELCH, MJ
通讯作者：
WELCH, MJ
影响因子：
3.1
作者：
Römer, J;Füchtner, F;Johanssen, B
通讯作者：
Johanssen, B
DOI：
10.1007/s00259-002-0974-3
发表时间：
2002-12-01
影响因子：
9.1
作者：
Erselcan, T;Turgut, B;Ozdemir, S
通讯作者：
Ozdemir, S