Innate allorecognition by monocytic cells and its role in graft rejection.
Innate allorecognition by monocytic cells and its role in graft rejection.
复制标题
单核细胞的先天同种异体及其在移植排斥中的作用。
DOI：
10.1111/ajt.14436
复制
发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Li XC
中科院分区：
文献类型：
--
作者：
Lakkis FG;Li XC
单核细胞和巨噬细胞对微生物产物和危险分子的先天识别已经得到很好的建立;这主要由模式识别受体介导，并且是激活生产性免疫所需的先天和适应性免疫细胞的核心。单核细胞和巨噬细胞是否具有同种异体识别系统，使它们能够直接对同种异体移植物产生反应，这是一个备受争议的话题。最近的研究提供了令人信服的证据表明，这些细胞能够识别同种异体实体，并通过直接细胞毒性和同种异体反应性T细胞的引发介导移植物排斥反应。这些研究还揭示了基于供体细胞上多态性分子SIRPα的检测的先天同种异体识别机制。进一步了解先天性同种异体识别及其后果将为同种异体移植排斥反应提供重要的见解，并为移植患者提供更好的治疗。细胞、组织或器官在遗传上不同的个体之间的移植对宿主免疫系统构成持续的挑战。移植物的缺血再灌注损伤、对宿主的手术创伤、应激细胞释放危险分子、暴露于微生物产物以及主要和次要组织不相容性抗原的负担是受体免疫和炎症系统的强有力刺激物。因此，移植物排斥涉及多种免疫细胞，包括先天性和适应性细胞，这在临床移植中难以完全控制，这并不奇怪。
Innate recognition of microbial products and danger molecules by monocytes and macrophages has been well established; this is mediated primarily by pattern recognition receptors and is central to activation of innate and adaptive immune cells required for productive immunity. Whether monocytes and macrophages are equipped with an allorecognition system that allows them to directly respond to allogeneic grafts is a topic of much debate. Recent studies provide compelling evidence that these cells are capable of recognizing allogeneic entities and mediate graft rejection via direct cytotoxicity and priming of alloreactive T cells. These studies have also uncovered a mechanism of innate allorecognition based on detection of the polymorphic molecule SIRPα on donor cells. Further understanding of innate allorecognition and its consequences would provide essential insights into allograft rejection and lead to better therapies for transplant patients. Transplantation of cells, tissues, or organs between genetically-distinct individuals poses a persistent challenge to the host immune system. Ischemia reperfusion injury of the graft, surgical trauma to the host, release of danger molecules by stressed cells, exposure to microbial products, as well as the burden of major and minor histoincompatibility antigens are powerful stimulators of the recipient’s immune and inflammatory systems. It is therefore not surprising that graft rejection involves multiplicity of immune cells, including innate and adaptive cells, which have been difficult to fully control in clinical transplantation.
登录
查看更多内容
影响因子：
82.9
作者：
Liu X;Pu Y;Cron K;Deng L;Kline J;Frazier WA;Xu H;Peng H;Fu YX;Xu MM
通讯作者：
Xu MM
影响因子：
15.9
作者：
Oberbarnscheidt, Martin H.;Zeng, Qiang;Lakkis, Fadi G.
通讯作者：
Lakkis, Fadi G.
影响因子：
15.9
作者：
Liu, Quan;Rojas-Canales, Darling M.;Morelli, Adrian E.
通讯作者：
Morelli, Adrian E.
影响因子：
4.4
作者：
Chow, Kevin V.;Delconte, Rebecca B.;Lew, Andrew M.
通讯作者：
Lew, Andrew M.
DOI：
10.1126/science.1183021
发表时间：
2010-01-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Iwasaki A;Medzhitov R
通讯作者：
Medzhitov R