Predicting factors for endometrial thickness during treatment with assisted reproductive technology
Predicting factors for endometrial thickness during treatment with assisted reproductive technology
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DOI：
10.1016/j.fertnstert.2006.11.002
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发表时间：
2007-04-01
影响因子：
6.7
通讯作者：
Adrian, Shulman
中科院分区：
文献类型：
--
作者：
Amir, Wiser;Micha, Baum;Adrian, Shulman
目的：目的：探讨子宫内膜厚度的影响因素，并根据这些因素评价子宫内膜厚度对妊娠率的影响。设计：回顾性研究。地点：某大学医院体外受精室。患者：8月9日至2013年8月10日期间，所有原发性不孕且既往未怀孕的妇女在以色列Tel Hashomer的Chaim Sheba医疗中心接受IVF治疗，2001年至2004年12月31日。干预：在IVF周期中给予hCG当天使用经阴道超声探头测量子宫内膜厚度。主要结果测量（S）：影响子宫内膜厚度的因素以及子宫内膜厚度与PR之间的关系。年龄< 25岁的患者子宫内膜最厚（11.9 ± 2.5 mm），年龄> 40岁的患者子宫内膜最薄（9.6 ± 2.3 mm）。其他因素，如E-2水平，不孕症的病因，诱导排卵协议，和使用的促性腺激素的类型，也被发现有助于子宫内膜thicken. Conclusions（S）：我们的数据支持的情况下，一个“老化”的子宫内膜。年龄> 40岁的患者获得厚子宫内膜的机会低于年轻患者。此外，只有年龄> 35岁的患者，子宫内膜增厚与PR升高相关。
Objective: To discover the factors contributing to endometrial thickness, and to assess the impact of endometrial thickness on pregnancy rates PRs) according to these factors.Design: Retrospective study.Setting: In vitro fertilization unit in a university hospital.Patient(s): All women with primary infertility and no previous pregnancies who underwent IVF treatment at the Chaim Sheba Medical Center, Tel Hashomer, Israel, between August 9, 2001-December 31, 2004.Intervention: Measurement of endometrial thickness by the use of transvaginal ultrasound probe on the day that hCG was administered during an IVF cycle.Main Outcome Measure(S): Factors influencing endometrial thickness and the relationship between endometrial thickness and PRs.Result(s): The mean endometrial thickness decreased as a function of the patient's age. The thickest endometrium was found in patients < 25 years of age (11.9 +/- 2.5 mm), and the thinnest endometrium was found in patients > 40 years of age (9.6 +/- 2.3 mm). Other factors, such as E-2 levels, etiology of infertility, induction of ovulation protocol, and type of gonadotropin used, were also found to contribute to endometrial thickness.Conclusion(s): Our data support the case for an "aging" of the endometrium. The chances of achieving a thick endometrium for patients > 40 years of age are lower than for younger patients. Furthermore, a thicker endometrium is correlated with a higher PR only for patients > 35 years of age.