Neutrophil migration in infection and wound repair: going forward in reverse.
Neutrophil migration in infection and wound repair: going forward in reverse.
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DOI：
10.1038/nri.2016.49
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发表时间：
2016-05-27
期刊：
影响因子：
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通讯作者：
Huttenlocher A
中科院分区：
文献类型：
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作者：
de Oliveira S;Rosowski EE;Huttenlocher A
在过去的十年中，神经元迁移及其在炎症中的作用一直是人们关注的焦点。活体成像的进展和新模型系统的使用有助于揭示受伤和感染组织中中性粒细胞的行为。尽管中性粒细胞被认为是在受损组织中经历凋亡的短寿命效应细胞，但最近的证据表明中性粒细胞的行为更复杂，并且在某些情况下，中性粒细胞可能离开组织损伤部位并迁移回脉管系统。反向迁移的作用及其对炎症消退的贡献仍不清楚。在这里，我们讨论了不同的组织内的线索，介导中性粒细胞的前向和反向迁移，以响应损伤或感染，以及这些机制对人类疾病的影响。中性粒细胞遵循多种信号到达损伤或感染部位。了解这是如何发生的，以及这些中性粒细胞的命运是什么，可以深入了解免疫反应是如何控制和避免慢性炎症的。在这里，作者描述了炎症过程中中性粒细胞的运动。
Neutrophil migration and its role during inflammation has been the focus of increased interest in the past decade. Advances in live imaging and the use of new model systems have helped to uncover the behaviour of neutrophils in injured and infected tissues. Although neutrophils were considered to be short-lived effector cells that undergo apoptosis in damaged tissues, recent evidence suggests that neutrophil behaviour is more complex and, in some settings, neutrophils might leave sites of tissue injury and migrate back into the vasculature. The role of reverse migration and its contribution to resolution of inflammation remains unclear. Here, we discuss the different cues within tissues that mediate neutrophil forward and reverse migration in response to injury or infection, and the implications of these mechanisms to human disease. Neutrophils follow a multitude of signals to reach sites of injury or infection. Understanding how this occurs and what the fate of these neutrophils is provides insight into how immune responses are controlled and chronic inflammation avoided. Here, the authors describe the movement of neutrophils during inflammation.