The MATRICS consensus cognitive battery, part 2: Co-norming and standardization
The MATRICS consensus cognitive battery, part 2: Co-norming and standardization
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DOI：
10.1176/appi.ajp.2007.07010043
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发表时间：
2008-02-01
影响因子：
17.7
通讯作者：
Marder, Stephen R.
中科院分区：
文献类型：
--
作者：
Kern, Robert S.;Nuechterlein, Keith H.;Marder, Stephen R.
目的：由美国国家精神卫生研究所（NIMH）的测量和治疗研究开发的共识认知电池，以改善精神分裂症的认知（MATRICS）倡议包括10个独立开发的测试，被推荐为精神分裂症认知增强干预临床试验的标准电池。为了便于解释的结果，从MATRICS共识认知电池使用一个共同的缩放跨测试，规范性数据从一个单一的代表性的美国社区样本与电池管理作为一个unit.Method：MATRICS共识认知电池管理到300个人从一般社区在5个站点在不同的地理区域。对于每个研究中心，招募按年龄、性别和教育程度分层。采用科学的调查抽样方法，避免抽样偏差。在持续约60分钟的单次会议中，以标准顺序向每位参与者施用电池。描述性数据的产生，和年龄，性别和教育对性能的影响进行了examined.Results：突出的年龄和教育的影响，观察跨测试。性别的结果因措施而异，这表明在临床试验中需要进行年龄和性别校正。的MATRICS共识认知电池组件共同规范，与津贴人口corrections.Conclusions：共同规范电池，如MATRICS共识认知电池，包括测试独立的测试开发商各自有自己的一套规范，有利于有效的解释测试成绩和跨研究的结果沟通。这些规范性数据将有助于估计认知增强剂临床试验期间的变化幅度，并有可能获得更直接的可解释的综合评分。
Objective: The consensus cognitive battery developed by the National Institute of Mental Health's (NIMH's) Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative includes 10 independently developed tests that are recommended as the standard battery for clinical trials of cognition-enhancing interventions for schizophrenia. To facilitate interpretation of results from the MATRICS Consensus Cognitive Battery using a common scaling across tests, normative data were obtained from a single representative U.S. community sample with the battery administered as a unit.Method: The MATRICS Consensus Cognitive Battery was administered to 300 individuals from the general community at five sites in differing geographic regions. For each site, recruitment was stratified by age, gender, and education. A scientific survey sampling method was used to help avoid sampling bias. The battery was administered in a standard order to each participant in a single session lasting approximately 60 minutes. Descriptive data were generated, and age, gender, and education effects on performance were examined.Results: Prominent age and education effects were observed across tests. The results for gender differed by measure, suggesting the need for age and gender corrections in clinical trials. The MATRICS Consensus Cognitive Battery components were co-normed, with allowance for demographic corrections.Conclusions: Co-norming a battery such as the MATRICS Consensus Cognitive Battery, comprising tests from independent test developers each with their own set of norms, facilitates valid interpretation of test scores and communication of findings across studies. These normative data will aid in estimating the magnitude of change during clinical trials of cognition-enhancing agents and make it possible to derive more directly interpretable composite scores.