The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
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DOI：
10.4137/bmimi.s20061
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发表时间：
2015-01-01
影响因子：
3.8
通讯作者：
Coulombe, Kareen L. K.
中科院分区：
文献类型：
--
作者：
Rupert, Cassady E.;Coulombe, Kareen L. K.
Neuregulin-1 (NRG-1) 及其信号受体、红细胞白血病病毒癌基因同源物 (ErbB) 2、3 和 4 与心肌细胞发育和疾病以及稳态心脏功能有关。 NRG-1/ErbB 信号传导参与多种心脏过程，从心肌和心脏传导系统发育到心肌细胞的血管生成支持，再到损伤时的心脏保护作用。 NRG-1 的大量研究采用了各种平台，包括体外测定、动物模型和人体临床试验，结果同样各不相同，有时甚至是矛盾的。 NRG-1有潜力用作干细胞疗法、组织工程应用以及临床诊断和治疗中的治疗工具。这篇综述对越来越多的文献进行了简要总结，以强调 NRG-1/ErbB 信号在心脏（特别是心肌细胞）整个发育、稳态和疾病过程中的暂时持续重要性。
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function. NRG-1/ErbB signaling is involved in a multitude of cardiac processes ranging from myocardial and cardiac conduction system development to angiogenic support of cardiomyocytes, to cardioprotective effects upon injury. Numerous studies of NRG-1 employ a variety of platforms, including in vitro assays, animal models, and human clinical trials, with equally varying and, sometimes, contradictory outcomes. NRG-1 has the potential to be used as a therapeutic tool in stem cell therapies, tissue engineering applications, and clinical diagnostics and treatment. This review presents a concise summary of the growing body of literature to highlight the temporally persistent significance of NRG-1/ErbB signaling throughout development, homeostasis, and disease in the heart, specifically in cardiomyocytes.