A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue
A case of peripheral T-cell lymphoma unspecified involving subcutaneous tissue
复制标题
累及皮下组织的未明确外周T细胞淋巴瘤一例
作者：
A. Futagami;M. Aoki;S. Kawana
一位36岁的男性，在他的左大腿上有一个3岁的红棕色斑块伴皮下结节。虽然3年前在他的右大腿上观察到类似的病变，但1年后该病变自行消失。然而，左大腿的病变越来越大。组织学上，病变表现为弥漫性和致密的非典型淋巴细胞浸润，从真皮浅层延伸到皮下组织。在皮下脂肪组织中观察到由中小型非典型淋巴细胞和大型正常组织细胞组成的重度小叶脂膜炎。免疫组织化学研究显示胸腺后T细胞表型。遗传分析表明T细胞受体链基因重排。左侧皮肤病变也逐渐消失后，皮肤活检未经治疗，他继续在缓解。
A 36-year-old man presented with a 3-year-old red-brown plaque with subcutaneous nodules on his left thigh. Although a similar lesion was observed on his right thigh 3 years earlier, it spontaneously disappeared 1 year later. However, the lesion on the left thigh was growing larger. Histologically, the lesion showed a diffuse and dense infiltration of atypical lymphocytes extending from the superficial dermis to the subcutaneous tissue. Severe lobular panniculitis, composed of small- and medium-sized atypical lymphocytes and large normal histiocytes, was observed in the subcutaneous adipose tissue. Immunohistochemical studies revealed a post-thymic T-cell phenotype. A genetic analysis demonstrated a rearrangement of the T-cell receptor chain gene. The left skin lesion also gradually disappeared after skin biopsy without therapy, and he continues to be in remission.