3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration †
3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration †
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DOI：
10.3390/mi6040437
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发表时间：
2015-04-01
期刊：
影响因子：
3.4
通讯作者：
Filippini, Daniel
中科院分区：
文献类型：
--
作者：
Comina, German;Suska, Anke;Filippini, Daniel
一体式芯片实验室（UNODC）概念需要围绕单个单片3D打印元件（一体式）构建快速且经济实惠的微型原型系统。消费级立体光刻（SL）3D打印机可以配置具有不同形式的样品输送，运输，处理和读出的ULOC，同时最大限度地减少材料成本和制造时间。ULOC集中了所有复杂的制造程序，并取代了对洁净室资源的需求，以不到1美元的价格交付原型，可以在10分钟内打印，并在不到30分钟内准备好进行测试。讨论了ULOC集成运输、光学读出化学传感和流动混合能力的最新示例，以及ULOC设备第一个止回阀的集成。单向阀是严格的单向高达100 psi，显示指数向前流动行为高达70 psi，可以完全制造的单向阀的方法。
The unibody lab-on-a-chip (ULOC) concept entails a fast and affordable micro-prototyping system built around a single monolithic 3D printed element (unibody). A consumer-grade stereo lithography (SL) 3D printer can configure ULOCs with different forms of sample delivery, transport, handling and readout, while minimizing material costs and fabrication time. ULOC centralizes all complex fabrication procedures and replaces the need for clean room resources, delivering prototypes for less than 1 US$, which can be printed in 10 min and ready for testing in less than 30 min. Recent examples of ULOC integration of transport, chemical sensing for optical readout and flow mixing capabilities are discussed, as well as the integration of the first check-valves for ULOC devices. ULOC valves are strictly unidirectional up to 100 psi, show an exponential forward flow behavior up to 70 psi and can be entirely fabricated with the ULOC approach.