Human parathyroid hormone (1–34) and (1–84) increase the mechanical strength and thickness of cortical bone in rats
Human parathyroid hormone (1–34) and (1–84) increase the mechanical strength and thickness of cortical bone in rats
复制标题
人甲状旁腺激素 (1–34) 和 (1–84) 增加大鼠皮质骨的机械强度和厚度
DOI：
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发表时间：
1993
影响因子：
6.2
通讯作者：
M. Nilsson
中科院分区：
文献类型：
--
作者：
C. Ejersted;T. Andreassen;H. Oxlund;P. Jørgensen;B. Bak;J. Häggblad;O. Tørring;M. Nilsson
间歇性甲状旁腺激素（PTH）治疗对骨的合成代谢作用已在骨质疏松症患者和实验动物中发现。然而，关于骨小梁平衡的积极作用是否以牺牲皮质骨为代价存在争议。我们检查了不同剂量PTH间歇治疗后皮质骨的生物力学质量，并进一步比较了PTH-（1-34）和PTH-（1-84）的作用。大鼠组接受生物合成人PTH-（1-34）或PTH-（1-84）治疗，剂量为1.1、3.3、10或30 nmol/kg/天，持续30天。PTH处理后，未观察到体重变化和股骨长度变化。通过材料试验机分析生物力学性能。发现股骨的弯曲强度和刚度呈剂量相关性增加，并且这种机械强度增加对应于股骨干横截面积增加9-12%。的偏转能力和能量吸收不受任何PTH处理。PTH-（1-34）或PTH-（1-84）对股骨生物力学性能的影响无差异。因此，使用生物合成PTH-（1-34）或PTH-（1-84）进行间歇性治疗增加了皮质骨的形成，并且发现股骨的生物力学能力得以保留。
An anabolic effect on bone of intermittent parathyroid hormone (PTH) treatment has been found in patients with osteoporosis and also in experimental animals. Controversies exist, however, about whether the positive effect on the trabecular bone balance occurs at the expense of the cortical bone. We examined the biomechanical quality of cortical bone after intermittent treatment with different doses of PTH and, furthermore, compared the effects of PTH‐(1–34) and PTH‐(1–84). Groups of rats were treated with biosynthetic human PTH‐(1–34) or PTH‐(1–84), 1.1, 3.3, 10, or 30 nmol/kg/day for 30 days. No changes in the body weights and no changes in the lengths of the femora were observed after the PTH treatments. The bio‐mechanical properties were analyzed by means of a materials‐testing machine. A dose‐related increase in the bending strength and stiffness of the femora was found, and this increase in mechanical strength corresponds with a 9–12% increase in the cross‐sectional area of the femoral diaphyses. The deflection capability and energy absorption were not influenced by any of the PTH treatments. No differences were found between the effects of PTH‐(1–34) or PTH‐(1–84) on the biomechanical properties of the femora. Consequently, intermittent treatment with biosynthetic PTH‐(1–34) or PTH‐(1–84) increased the formation of cortical bone, and the biomechanical competence of the femora was found to be preserved.
影响因子：
4.8
作者：
MCCARTHY, TL;CENTRELLA, M;CANALIS, E
通讯作者：
CANALIS, E
DOI：
10.1097/00006254-199008000-00016
发表时间：
1990-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
B. Riggs;S. Hodgson;W. O'Fallon;E. Chao;H. Wahner;J. Muhs;S. L. Cedel;L. Joseph Melon
通讯作者：
B. Riggs;S. Hodgson;W. O'Fallon;E. Chao;H. Wahner;J. Muhs;S. L. Cedel;L. Joseph Melon
甲状旁腺激素和甲状旁腺激素相关肽通过腺苷 3,5-单磷酸依赖性机制刺激大鼠成骨细胞样细胞分泌胰岛素样生长因子结合蛋白。
影响因子：
4.8
作者：
Torring,O;Firek,AF;Heath3rd,H;Conover,CA
通讯作者：
Conover,CA