Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele
Increased risk for major depression associated with the short allele of the serotonin transporter promoter region (5-HTTLPR-S) and the CYP2C9*3 allele
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DOI：
10.1111/j.1472-8206.2007.00501.x
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发表时间：
2007-08-01
影响因子：
2.9
通讯作者：
LLerena, A.
中科院分区：
文献类型：
--
作者：
Dorado, P.;Penas-Lledo, E. M.;LLerena, A.
在本研究中，我们旨在分析5-羟色胺转运体(SERT或5-HTT)基因启动子区(5-HTTLPR)多态与患重度抑郁症(MDD)的风险之间的潜在相关性。70名患有MDD的欧洲白人精神科门诊患者和142名健康志愿者(HV)进行了研究。MDD组携带5-HTTLPR-S等位基因的频率高于HV组(P<0.05)。5-HTTLPR-S等位基因在MDD组与HV组的优势比为2.03。此前，我们在该人群中发现，在MDD患者中，CYP2C9*3等位基因频率高于HV患者。MDD组携带5-HTTLPR-S和CYP2C9*3等位基因的频率明显高于HV组(P<；0.01，优势比3.47)。本研究结果为同时携带5-HTTLPR-S和CYP2C9*3等位基因的个体罹患MDD的风险增加提供了初步证据。
In the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter (SERT or 5-HTT) gene (5-HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Seventy white European psychiatric outpatients suffering from MDD and a group of 142 healthy volunteers (HVs) were studied. The frequency of subjects carrying the 5-HTTLPR-S allele was higher (P < 0.05) among MDD than in HV. The odds ratio associated with 5-HTTLPR-S allele was 2.03 for the MDD patients in comparison with the HV group. Previously, we found in this population that the CYP2C9*3 allele frequency was higher among this population of MDD patients than in HV. The frequency of subjects with the combination 5-HTTLPR-S and CYP2C9*3 alleles was higher (P < 0.01, odds ratio 3.47) in MDD than in HV. The present findings provide preliminary evidence about the greater risk of suffering MDD for individuals carrying both 5-HTTLPR-S and CYP2C9*3 alleles.