Pre-pandemic Cognitive Function and COVID-19 Vaccine Hesitancy: Cohort Study.
Pre-pandemic Cognitive Function and COVID-19 Vaccine Hesitancy: Cohort Study.
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大流行前认知功能和 COVID-19 疫苗犹豫：队列研究。
DOI：
10.1101/2021.03.16.21253634
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Altschul,Drew
中科院分区：
文献类型：
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作者：
Batty,GDavid;Deary,IanJ;Fawns-Ritchie,Chloe;Gale,CatharineR;Altschul,Drew
背景虽然已经报道了COVID-19疫苗犹豫的几个预测因素，但认知功能的作用在很大程度上是未知的。因此，我们的目标是评估在宣布成功测试第一种COVID-19疫苗（牛津大学/阿斯利康）后，一系列认知功能测试的分数与自我报告的疫苗犹豫之间的关联。方法我们使用了来自以流行病为重点的研究（“COVID调查”）的个人水平数据，这是一项嵌套在英国理解协会（“主要调查”）内的前瞻性队列研究。在宣布成功测试首次有效接种后的一周内（2020年11月/12月），收集了11，740名16-95岁的人（6702名女性）的疫苗意向数据。在2011/12年度的主要统计调查中，我们收集了流感大流行前的一般认知功能评分，这些评分是从一组六项测试中确定的。在COVID-19调查中，研究成员自我报告了他们接种疫苗的意图。结果在研究样本中，17.2%（N = 1842）表示他们对接种疫苗犹豫不决。在对年龄、性别和种族进行调整后，基线认知评分较低的研究成员明显更有可能对疫苗犹豫不决（认知评分较低标准差的比值比; 95%置信区间：1.76; 1.62，1.90）。心理和身体健康加上家庭屏蔽状态的调整对这些结果没有影响，而控制教育程度导致部分衰减，但犹豫的概率仍然升高（1.52; 1.37，1.67）。在整个认知得分范围内，疫苗犹豫呈线性相关（p趋势：p < 0.0001）。结论错误的社交媒体报道可能会使个人决策复杂化，导致认知能力较低的人对疫苗犹豫不决。在疫苗分发之前进行的研究中，认知能力较低的个体也经历了较高的COVID-19发病率，这些新发现表明潜在的额外疾病负担。
BackgroundWhereas several predictors of COVID-19 vaccine hesitancy have been reported, the role of cognitive function is largely unknown. Accordingly, our objective was to evaluate the association between scores from an array of cognitive function tests and self-reported vaccine hesitancy after the announcement of the successful testing of the first COVID-19 vaccine (Oxford University/AstraZeneca).MethodsWe used individual-level data from a pandemic-focused study ('COVID Survey'), a prospective cohort study nested within United Kingdom Understanding Society ('Main Survey'). In the week immediately following the announcement of successful testing of the first efficacious inoculation (November/December 2020), data on vaccine intentionality were collected in 11,740 individuals (6702 women) aged 16–95 years. Pre-pandemic scores on general cognitive function, ascertained from a battery of six tests, were captured in 2011/12 wave of the Main Survey. Study members self-reported their intention to take up a vaccination in the COVID-19 Survey.ResultsOf the study sample, 17.2% (N = 1842) indicated they were hesitant about having the vaccine. After adjustment for age, sex, and ethnicity, study members with a lower baseline cognition score were markedly more likely to be vaccine hesitant (odds ratio per standard deviation lower score in cognition; 95% confidence interval: 1.76; 1.62, 1.90). Adjustment for mental and physical health plus household shielding status had no impact on these results, whereas controlling for educational attainment led to partial attenuation but the probability of hesitancy was still elevated (1.52; 1.37, 1.67). There was a linear association for vaccine hesitancy across the full range of cognition scores (p for trend: p < 0.0001).ConclusionsErroneous social media reports might have complicated personal decision-making, leading to people with lower cognitive ability being vaccine-hesitant. With individuals with lower cognition also experiencing higher rates of COVID-19 in studies conducted prior to vaccine distribution, these new findings are suggestive of a potential additional disease burden.