Fabrication of porous hydroxyapatite bodies by a new direct consolidation method: starch consolidation.
Fabrication of porous hydroxyapatite bodies by a new direct consolidation method: starch consolidation.
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通过一种新的直接固结方法制备多孔羟基磷灰石体：淀粉固结。
DOI：
10.1002/jbm.10036
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
J. Ferreira
中科院分区：
文献类型：
--
作者：
L. Rodríguez;M. Vallet‐Regí;J. Ferreira
发展了一种新的直接固结法--“淀粉固结法”，用于制备不同孔径和孔体积分数的羟基磷灰石（OHAp）坯体。该方法基于淀粉在水存在下加热至80摄氏度时的溶胀能力。在本工作中使用通过沉淀法制备并在900 ℃下热处理以获得用于胶体加工的适当比表面积的OHAp粉末。需要湿法球磨以使粉末解聚并提高其加工能力。将不同的淀粉体积分数和淀粉颗粒尺寸添加到OHAp浆料中，然后对其进行热处理以通过淀粉凝胶化促进固结。观察到计划孔隙度值与实测孔隙度值之间存在线性关系。SEM照片显示存在相互连接的孔，其形状和尺寸与所使用的淀粉颗粒相对应。对于约70%和45%的孔体积分数，弯曲强度分别从约2至15 MPa变化。在脱细胞合成体液（SBF）中的降解研究表明，在研究时间内，制备的身体在生理条件下保持其完整性。该方法提供了制造可用作支架工程和/或药物受控递送系统的材料的可能性。
A new direct consolidation method known as "starch consolidation" was developed especially for the fabrication of porous ceramics, as adopted to prepare hydroxyapatite (OHAp) bodies with different pore sizes and pore volume fractions. The method is based on the swelling ability of starch when it is heated to 80 degrees C in the presence of water. An OHAp powder prepared by a precipitation method and heat treated at 900 degrees C to obtain an appropriate specific surface area for colloidal processing was used in the present work. Wet ball milling was required to deagglomerate the powder and improve its processing ability. Different starch volume fractions and starch particle sizes were added to the OHAp slurries, which were then heat treated to promote consolidation by starch gelification. A linear relationship between the planned and measured porosity values was observed. SEM pictures reveal the presence of interconnected pores with shape and sizes corresponding to starch granules used. Flexural strength varied from about 2 to 15 MPa, for pore volume fractions of approximately 70 and 45%, respectively. A degradation study in an acellular synthetic body fluid (SBF) has shown that the prepared bodies keep their integrity under physiological conditions during the studied time. The method offers possibilities of manufacturing materials that can be used as scaffolds engineering and/or systems for controlled delivery of drugs.