NICOTINE INCREASES SENSORY GATING MEASURED AS INHIBITION OF THE ACOUSTIC STARTLE REFLEX IN RATS
NICOTINE INCREASES SENSORY GATING MEASURED AS INHIBITION OF THE ACOUSTIC STARTLE REFLEX IN RATS
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DOI：
10.1007/bf02244861
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发表时间：
1994-03-01
影响因子：
3.4
通讯作者：
GRUNBERG, NE
中科院分区：
文献类型：
--
作者：
ACRI, JB;MORSE, DE;GRUNBERG, NE
据报道，长期服用尼古丁会增加大鼠的声惊反应（ASR）振幅，这为某些剂量的尼古丁可以增强注意力提供了证据。本实验研究了急性给药尼古丁对大鼠声惊吓振幅和脉冲前抑制（PPI）的影响。PPI，即由刺激引起的ASR振幅的下降，反映了感觉门控背后的注意前神经过程。尼古丁对惊吓幅度有双相剂量效应，低剂量（0.01 mg/kg）增加，高剂量（0.5 ~ 5.0 mg/kg）降低。较低剂量的尼古丁（0.001 ~ 0.01 mg/kg）增加了PPI， 0.001 mg/kg的增加与ASR振幅的变化无关。这些结果证实PPI的增加不依赖于ASR振幅的变化。结果与尼古丁在人类认知任务中的表现增强一致，并且是首次报道使用PPI范式来模拟这种效果。这些发现表明ASR范式对研究尼古丁的影响是有用的。
Chronic nicotine administration has been reported to increase acoustic startle response (ASR) amplitude in rats, which has been offered as evidence that some dosages of nicotine can enhance attention. The present experiments examined effects of acutely administered nicotine on amplitude and pre-pulse inhibition (PPI) of acoustic startle in rats. PPI, the decrease in ASR amplitude by a stimulus preceding the startle-eliciting event, reflects pre-attentive neural processes underlying sensory gating. Nicotine had a biphasic dose effect on startle amplitude, with increases at lower dosages (0.01 mg/kg) and decreases at higher dosages (0.5-5.0 mg/kg SC). Lower dosages of nicotine (0.001-0.01 mg/kg) increased PPI and the increase at 0.001 mg/kg occurred independently of changes in ASR amplitude. These results confirm that increases in PPI are not dependent upon changes in ASR amplitude. Results are consistent with nicotine's enhancements of performance on cognitive tasks in humans and are the first reported use of the PPI paradigm to model such effects. These findings indicate that ASR paradigms are useful to study effects of nicotine.