SERUM-INSULIN AND OTHER CARDIOVASCULAR RISK INDICATORS IN CHILDREN, ADOLESCENTS AND YOUNG-ADULTS
SERUM-INSULIN AND OTHER CARDIOVASCULAR RISK INDICATORS IN CHILDREN, ADOLESCENTS AND YOUNG-ADULTS
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DOI：
10.3109/07853899109147933
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发表时间：
1991-02-01
影响因子：
4.4
通讯作者：
AKERBLOM, HK
中科院分区：
文献类型：
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作者：
RONNEMAA, T;KNIP, M;AKERBLOM, HK
我们想确定生长过程中空腹血清胰岛素水平，血清胰岛素的跟踪，以及儿童和年轻人血清胰岛素与其他冠心病风险指标的相关性。1986年，研究了2433名9 - 24岁的受试者，并从1980年和1983年的同一人群中获得了胰岛素数据。血清胰岛素水平在青春期出现高峰，在21岁以后胰岛素水平继续下降。血清胰岛素的追踪仅为中度，尤其是在女性和年轻男孩中。血清胰岛素与体重指数、血清甘油三酯浓度和血压呈正相关，与高密度脂蛋白胆固醇浓度呈负相关。高甘油三酯、高收缩压和低水平高密度脂蛋白胆固醇聚集在最高胰岛素四分位数的受试者中。我们的研究结果表明，胰岛素抵抗现象，主要是由肥胖引起的，并导致其他冠心病风险指标的不利水平，已经在儿童和年轻人中发展。这表明在生命早期预防肥胖很重要。
We wanted to determine the levels of fasting serum insulin during growth, the tracking of serum insulin, and the correlation of serum insulin with other coronary heart disease risk indicators in children and young adults. In 1986 2433 subjects, aged nine to 24 were studied, and insulin data were available from the same population in 1980 and 1983. Serum insulin levels showed a peak during puberty in both sexes and the decline in insulin continued after the age of 21. Tracking of serum insulin was only moderate, especially in females and young boys. Serum insulin correlated positively with body mass index, concentrations of serum triglycerides, and blood pressure, and inversely with the concentration of high density lipoprotein cholesterol. High triglycerides, high systolic blood pressure, and low level of high density lipoprotein cholesterol clustered among subjects within the highest insulin quartile. Our results suggest that the insulin resistance phenomenon, caused mainly by obesity and leading to unfavourable levels of other coronary heart disease risk indicators, is already developing in children and young adults. This suggests that preventing obesity in early life is important.