Factors influencing the vitamin D status of 10-year-old urban South African children
Factors influencing the vitamin D status of 10-year-old urban South African children
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DOI：
10.1017/s136898001000234x
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发表时间：
2011-02-01
影响因子：
3.2
通讯作者：
Pettifor, John M.
中科院分区：
文献类型：
--
作者：
Poopedi, Machuene A.;Norris, Shane A.;Pettifor, John M.
目的：评估城市10岁健康儿童的维生素D状况及其影响因素。设计：一项横断面研究。在一年的四季中采集血液样本，用于血清25-羟基维生素D[25(OH)D]的生化测定。测量人体测量(身高和体重)、BMI和总脂肪和瘦质量(由双能X射线吸收法测定)。25(OH)D浓度用化学发光法测定。背景：南非大约翰内斯堡地区构成纵向出生到20岁的骨健康亚队列的儿童的研究。对象：构成纵向出生到20岁的骨健康亚队列的385名儿童。结果：白人儿童的25(OH)D水平显著高于黑人同龄人(分别为120.0(SD36.6)nmol/L v.93.3(SD34.0nmol/L))。25(OH)D水平的季节变化只在白人儿童中发现，在秋季和夏季，白人儿童的25(OH)I水平显著高于黑人儿童。在多元回归分析中，季节、种族、性别和总脂肪质量是影响25(OH)D的因素。维生素D缺乏(7%)和不足(19%)在10岁儿童中不常见。结论：约翰内斯堡健康儿童不需要补充或强化维生素D。然而，进一步的研究需要在该国其他地区证实这一点，特别是在生活在更南边、冬季日照较少的地区。
Objective: Assessment of vitamin D status in a cohort of healthy 10-year-old urban children and the factors that influence vitamin D status in these children.Design: A cross-sectional study. Blood samples were collected across four seasons of the year for the biochemical determination of serum 25-hydroxyvitamin D [25(OH)D]. Anthropometric measurements (height and weight), BMI and total fat and lean mass (determined by the dual energy X-ray absorptiometry) were measured. 25(OH)D concentrations were assessed by chemiluminescent assay.Setting: Study of children in the Greater Johannesburg area of South Africa who form the Bone Health sub-cohort of the longitudinal Birth to Twenty cohort.Subjects: Three hundred and eighty-five children who form the Bone Health sub-cohort of the longitudinal Birth to Twenty cohort.Results: White children had significantly higher 25(OH)D than their black peers (120.0 (SD 36.6) nmol/l v. 93.3 (SD 34.0) nmol/l, respectively). Seasonal variations in 25(OH)D levels were found only in white children, with 25(OH)I) levels being significantly higher in white than in black children during the autumn and summer months. In multiple regression analysis, season, ethnicity, sex and total fat mass were the factors found to have an influence on 25(OH)D. Vitamin D deficiency (7%) and insufficiency (19%) were uncommon among the 10-year-old children.Conclusions: Vitamin D supplementation or fortification is not warranted in healthy children living in Johannesburg. However, further studies need to confirm this in other regions of the country, especially in those living further south and with less sunshine during the winter months.