Sliding into home: facilitated p53 search for targets by the basic DNA binding domain
Sliding into home: facilitated p53 search for targets by the basic DNA binding domain
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DOI：
10.1038/sj.cdd.4401905
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发表时间：
2006-06-01
影响因子：
12.4
通讯作者：
Kulesz-Martin, M. F.
中科院分区：
文献类型：
--
作者：
Liu, Y.;Kulesz-Martin, M. F.
The article discusses why p53 requires two DNA binding domains for its role as a tumor suppressor. P53 is a unique DNA binding protein with two distinct DNA binding domains, the central domain and the C-terminal basic DNA binding domain. The presence of two separate DNA binding domains with distinct DNA binding properties distinguishes p53 from each DNA binding proteins.
