Proton spectral editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivo
Proton spectral editing for discrimination of lactate and threonine 1.31 ppm resonances in human brain in vivo
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DOI：
10.1002/mrm.20988
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Allen, Peter S.
中科院分区：
文献类型：
--
作者：
Choi, Changho;Coupland, Nicholas J.;Allen, Peter S.
本文报道了一种在3 T条件下区分人脑中乳酸（Lac）和苏氨酸（Thr）1.31ppm共振的单体素质子NMR J-差编辑方法。一个双波段和两个三波段高斯180度RF脉冲，带宽均为15 Hz，采用绝热重聚焦双回波定位序列内诱导Lac和Thr的靶信号，并同时在每个子扫描中采集肌酸单线态。通过对滤波性能的数值分析，得到了最佳回波时间和编辑效率。从三个子光谱中提取Lac和Thr信号，没有脂质污染。使用计算的产率，人枕叶皮质中Lac和Thr的浓度估计分别为0.47 +/- 0.07和0.56 +/- 0.06 mM（平均值+/- SD，N = 7），参考8 mM的Cr。
A single-voxel proton NMR J-difference editing method for discriminating between the 1.31 ppm resonances of lactate (Lac) and threonine (Thr) in human brain in vivo at 3 T is reported. One double-band and two triple-band Gaussian 180 degrees RF pulses, all with a bandwidth of 15 Hz, were employed within an adiabatic-refocused double-echo localization sequence to induce the target signals of Lac and Thr and simultaneously acquire a creatine singlet in each subscan. The optimum echo time and the editing efficiency were obtained by numerical analysis of the filtering performance. The Lac and Thr signals were extracted, without lipid contamination, from three subspectra. Using the calculated yields, the concentrations of Lac and Thr in the human occipital cortex were estimated to be 0.47 +/- 0.07 and 0.56 +/- 0.06 mM (mean +/- SD, N = 7), respectively, with reference to Cr at 8 mM.