Response of forearm resistance vessels to verapamil and sodium nitroprusside in normotensive and hypertensive men: evidence for a functional abnormality of vascular smooth muscle in primary hypertension.
Response of forearm resistance vessels to verapamil and sodium nitroprusside in normotensive and hypertensive men: evidence for a functional abnormality of vascular smooth muscle in primary hypertension.
复制标题
血压正常和高血压男性前臂阻力血管对维拉帕米和硝普钠的反应：原发性高血压中血管平滑肌功能异常的证据。
作者：
B. Robinson;R. J. Dobbs;S. Bayley
1.用体积描记法对23例动脉血压正常的男性和35例原发性高血压男性的前臂阻力血管对局部动脉内注入维拉帕米和硝普钠的反应进行了评价。2.在20例测得全剂量-反应曲线的高血压患者中，维拉帕米对扩张器的反应显著大于正常对照组，而对硝普钠的反应则明显降低。3.比较个体受试者对两种扩张器的反应，可以减少两种药物共有变量的分散效应。用这种方法分析结果显示，高血压男性总体上与正常血压对照组之间存在非常显著的差异(P<0.00001)；35名高血压男性中有24人的反应超出了正常范围。4.高血压组的异常反应模式不能用血管结构的改变来解释，而是强烈提示血管平滑肌的功能异常。
1. The response of the forearm resistance vessels to local intra-arterial infusion of verapamil and sodium nitroprusside has been assessed by a plethysmographic method in 23 men with normal arterial pressure and 35 men with primary hypertension. 2. In the 20 patients with hypertension for whom full dose-response curves were determined, the dilator response to verapamil was significantly greater than that in the normal controls, whereas the response to sodium nitroprusside was reduced. 3. Comparison of responses to the two dilators in individual subjects enabled the scattering effect of variables common to both drugs to be reduced. Analysis of the results in this way showed a highly significant difference between the hypertensive men as a whole and the normotensive controls (P less than 0.00001); 24 out of the 35 hypertensive men showed responses that were outside the normal range. 4. The abnormal pattern of response observed in the hypertensive group cannot be accounted for by structural changes in the vessels and strongly suggests a functional abnormality of the vascular smooth muscle.