Yeasts and fluconazole susceptibility in the Philippines
Yeasts and fluconazole susceptibility in the Philippines
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DOI：
10.1023/a:1007025212469
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发表时间：
1999-01-01
期刊：
影响因子：
5.5
通讯作者：
Fromtling, RA
中科院分区：
文献类型：
--
作者：
Bulmer, GS;Marquez, ML;Fromtling, RA
本文报道了1997~1998年从菲律宾16个医疗中心分离的579株酵母菌的鉴定和氟康唑敏感性。酵母菌的种类分布如下（百分比）：白色念珠菌（49.6%）;近平滑型（17.2%）; tropicalis（14.9%）;光滑毛苔蛾（C. glabrata）6.2%; pelliculosa（4.3%）; krusei（2.4%）;季也蒙地（1.9%）;皮肤毛孢子菌（1.7%）;新型隐球菌（0.9%）;念珠菌（0.5%）; C. lusitaniae（0.2%）和酿酒酵母（0.2%）。使用琼脂纸片扩散法测定氟康唑的敏感性，结果表明，94%的菌株是敏感的，5%的剂量依赖性敏感，只有1%的耐药。所有分离的C.白色念珠菌对氟康唑敏感（一种为剂量依赖性敏感）。对氟康唑耐药的酵母菌仅有C. guillermondii（1株）、C. glabrata（3株）和C.近平滑（1株）。
Identification and fluconazole susceptibility of 579 yeasts isolated from patients in 16 medical centers throughout the Philippines in 1997-98 is reported. Speciation revealed the following distribution of yeasts (with percent occurrence): Candida albicans (49.6%); C. parapsilosis (17.2%); C. tropicalis (14.9%); C. glabrata (6.2%); C. pelliculosa (4.3%); C. krusei (2.4%); C. guilliermondii (1.9%); Trichosporon cutaneum (1.7%); Cryptococcus neoformans (0.9%); Candida famata (0.5%); C. lusitaniae (0.2%) and Saccharomyces cerevisiae (0.2%). Using an agar disk diffusion assay for fluconazole susceptibility it was determined that 94% of the isolates were susceptible, 5% dose-dependent susceptible and only 1% resistant. All isolates of C. albicans were susceptible (one being dose dependent sensitive) to fluconazole. The only yeasts resistant to fluconazole were: C. guillermondii (1 isolate), C. glabrata (3 isolates) and C. parapsilosis (1 isolate).