OTUB1 alleviates NASH through inhibition of the TRAF6‐ASK1 signaling pathways
OTUB1 alleviates NASH through inhibition of the TRAF6‐ASK1 signaling pathways
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DOI：
10.1002/hep.32179
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发表时间：
2021-09
期刊：
影响因子：
13.5
通讯作者：
J Zhang;Binbin Du;Dianhong Zhang;Huan Li;L. Kong;Guangjian Fan;Yapeng Li;Pengcheng Li;C. Liang;Zheng Wang;Lulu Yang;Zhengyang Hao;Leiming Wu;Zhen Huang;Jian-zeng Dong;Jin-ying Zhang;R. Yao;Shou-jun Wang;Yanzhou Zhang
中科院分区：
文献类型：
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作者：
J Zhang;Binbin Du;Dianhong Zhang;Huan Li;L. Kong;Guangjian Fan;Yapeng Li;Pengcheng Li;C. Liang;Zheng Wang;Lulu Yang;Zhengyang Hao;Leiming Wu;Zhen Huang;Jian-zeng Dong;Jin-ying Zhang;R. Yao;Shou-jun Wang;Yanzhou Zhang
NAFLD被认为是代谢综合征的肝脏表现，包括胰岛素抵抗、肥胖和高脂血症。NASH是NAFLD的进展期，伴有严重的肝脏脂肪变性、肝细胞死亡、炎症和纤维化。目前，没有专门为NASH量身定做的药物干预措施获得批准。卵巢肿瘤结构域泛素醛结合蛋白1(OTUB1)是去泛素酶的创始成员，调节着许多代谢相关的信号通路。然而，OTUB1在NASH中的作用尚不清楚。
NAFLD is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation, and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved. Ovarian tumor domain, ubiquitin aldehyde binding 1 (OTUB1), the founding member of deubiquitinases, regulates many metabolism‐associated signaling pathways. However, the role of OTUB1 in NASH is unclarified.