Germanene-Based Theranostic Materials for Surgical Adjuvant Treatment: Inhibiting Tumor Recurrence and Wound Infection
Germanene-Based Theranostic Materials for Surgical Adjuvant Treatment: Inhibiting Tumor Recurrence and Wound Infection
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DOI：
10.1016/j.matt.2020.04.022
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发表时间：
2020-07-01
期刊：
影响因子：
18.9
通讯作者：
Tao, Wei
中科院分区：
文献类型：
--
作者：
Feng, Chan;Ouyang, Jiang;Tao, Wei
锗烷烯（Ge）是一种新发现的二维（2D）单元素材料，其生物医学应用在很大程度上尚未探索。在这里，我们提供了基于2D Ge的手术辅助治疗策略的原理性证据。剥离的Ge纳米片（NS）表现出高载药能力，多响应（pH和近红外[NIR]敏感）的药物释放行为，NIR触发的深部肿瘤渗透，良好的生物相容性，以及出色的多模式成像引导治疗。当与水凝胶（由临床批准的琼脂糖和壳聚糖组成）组合时，开发的载药Ge@水凝胶在肿瘤切除后被涂覆在术后创面上。随后进行NIR照射，所产生的局部热疗和NIR触发的药物释放实现了立即的残留肿瘤消除和细菌杀灭效果，而水凝胶作为治疗储库，具有持久的抗肿瘤和杀菌效果。总之，这是基于2D Ge的手术辅助治疗的首次应用，可能标志着Ge生物医学应用的未来研究的起点。
Germanene (Ge) is a newly discovered two-dimensional (2D) mono-elemental material whose biomedical applications remain largely unexplored. Here, we provide the proof-of-principle evidence of a 2D Ge-based strategy for surgical adjuvant treatment. The exfoliated Ge nanosheets (NSs) exhibited high drug-loading capacity, multiresponsive (pH- and near-infrared [NIR]-sensitive) drug-release behavior, NIR-triggered deep tumor penetration, good biocompatibility, and excellent multimodal imaging-guided treatment. When combined with hydrogel (composed of clinically approved agarose and chitosan), the developed drug-loaded Ge@hydrogel was coated on the postoperative wound surface after tumor removal. Followed by NIR irradiation, the generated local hyperthermia and NIR-triggered drug release achieved immediate residual tumor-eliminating and bacteria-killing effects, while the hydrogel served as a therapeutic reservoir for long-lasting antitumor and bactericidal effects. In summary, this is the first application of 2D Ge-based surgical adjuvant treatment, potentially marking a jumping-off point for future studies on biomedical applications of Ge.