Get into the groove! Targeting antigens to MHC class II
Get into the groove! Targeting antigens to MHC class II
复制标题
进入凹槽！
作者：
J. Bergen;F. Ossendorp;R. Jordens;A. Mommaas;J. Drijfhout;F. Koning
摘要：MHC类限制性辅助性T细胞的激活对适应性免疫应答至关重要。因此，疫苗开发可能受益于将抗原靶向MHC II类分子的改进方法。近年来，人们利用MHC II类抗原递呈的自然途径来实现这一目标。首先，抗原蛋白和肽被修饰，以促进受体介导的抗原递呈细胞的摄取。其次，含有特定靶向序列的DNA构建体已被用于将内源性合成的抗原引导到MHC II类区室。事实证明，这两种策略都非常有效。我们回顾了这些数据，并描述了目前如何将这些知识应用于在体内激活辅助性T细胞的疫苗设计。
Summary: The activation of MHC class Il‐restricted helper T cells is paramount to adaptive immune responses. Vaccine development could therefore benefit from improved ways of targeting antigens into MHC class II molecules. In recent years, the natural pathways of MHC class II antigen presentation have been exploited to achieve this goal, First, antigenic proteins and peptides have been modified to facilitate receptor‐mediated uptake by professional antigen‐presenting cells. Second, DNA constructs containing specific targeting seqtiences have been used to direct endogenously synthesized antigens to the MHC dass II compartments. Both strategies proved to be highly effective. We review these data and describe how this knowledge is currently applied to the design of vaccines that activate helper T cells in vivo.
由单个肽结合的 II 类 MHC 蛋白的细胞表面表达。
DOI：
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发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Ignatowicz,L;Winslow,G;Bill,J;Kappler,J;Marrack,P
通讯作者：
Marrack,P
影响因子：
11.2
作者：
Ken Y. Lin;F. Guarnieri;K. Staveley-O’Carroll;H. Levitsky;J. August;D. Pardoll;T. Wu
通讯作者：
Ken Y. Lin;F. Guarnieri;K. Staveley-O’Carroll;H. Levitsky;J. August;D. Pardoll;T. Wu