Neural plasticity and stress induced changes in defense in the rat
Neural plasticity and stress induced changes in defense in the rat
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DOI：
10.1016/s0149-7634(01)00053-7
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发表时间：
2001-12-01
影响因子：
8.2
通讯作者：
Collins, A
中科院分区：
文献类型：
--
作者：
Adamec, RE;Blundell, J;Collins, A
我们研究了捕食者应激对大鼠行为和杏仁核传入和传出神经传递的影响。被研究的通路是：腹侧角束输入杏仁基底外侧核；中央和基底外侧杏仁核输出到中脑导水管周围灰质(PAG)。在应激一周后，在高架迷宫、明暗盒子和声学惊吓测试中，捕食者的应激是令人焦虑的。在神经传递方面也观察到了持久的变化。捕食者应激似乎增强了右侧和左侧大脑半球传入杏仁核的传递。相反，捕食者应激增强了杏仁核向左右PAG的传出传递，这取决于刺激的杏仁核。成对的脉冲和强度序列分析表明，传递的变化可能是突触后的，也可能是突触前的，这取决于路径。与大脑和行为变化相关的路径分析表明，两个半球的增强和去增强共同参与了捕食者压力产生的部分但不是全部行为变化的影响。左半球杏仁核传入和传出的增强预示着类焦虑的效应，而右半球杏仁核传入的增强则预示着类焦虑的效应。通径分析还支持这样的观点，即不同神经系统的变化会调节不同行为的变化。这些发现在猫身上的研究中也有相似之处，但也存在物种差异。(C)2002爱思唯尔科学有限公司。保留所有权利。
We investigated the effects of predator stress on behavior and amygdala afferent and efferent neural transmission in rats. Pathways studied were: ventral angular bundle input to the basolateral amygdala; central and basolateral amygdala output to the periaqueductal gray (PAG). Predator stress was 'anxiogenic' in elevated plus maze, light/dark box and acoustic startle tests one week after stress. Lasting changes were also observed in neural transmission. Predator stress appeared to potentiate right and depotentiate left hemisphere afferent amygdala transmission. In contrast, predator stress potentiated amygdala efferent transmission to right and left PAG, depending on the amygdala nucleus stimulated. Paired pulse and intensity series analysis suggests that transmission changes may be postsynaptic or presynaptic, depending on the pathway. Path analysis relating brain and behavioral changes suggests that potentiation and depotentiation in both hemispheres participate jointly in effecting some, but not all, of the behavioral changes produced by predator stress. Potentiation in left hemisphere amygdala afferents and efferents predicts anxiolytic-like effects, while potentiation in the right hemisphere amygdala afferents predicts anxiogenic-like effects. Path analysis also supports the view that changes in different neural systems mediate changes in different behaviors. These findings have their parallel in studies in the cat, but there are species differences. (C) 2002 Elsevier Science Ltd. All rights reserved.