Sucrose-based fabrication of 3D-networked, cylindrical microfluidic channels for rapid prototyping of lab-on-a-chip and vaso-mimetic devices
Sucrose-based fabrication of 3D-networked, cylindrical microfluidic channels for rapid prototyping of lab-on-a-chip and vaso-mimetic devices
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DOI：
10.1039/c2lc40267j
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发表时间：
2012-01-01
期刊：
影响因子：
6.1
通讯作者：
Kim, Jaeyoun
中科院分区：
文献类型：
--
作者：
Lee, Jiwon;Paek, Jungwook;Kim, Jaeyoun
我们提出了一种基于蔗糖纤维的成形、粘合和组装的三维网络圆柱形微流控(MF)通道的新制造方案。它是一种简单、无洁净室和环境友好的方法，非常适合芯片实验室设备的快速原型制作。尽管简单，但它可以实现复杂的3D中频通道架构，如圆柱形锥形、内部环路、端到侧连接、锥形连接和狭窄。后两者对于实现模拟血管的微血管结构具有特殊的作用。它还可以使用与高温加工不兼容的聚合物进行成型。
We present a new fabrication scheme for 3D-networked, cylindrical microfluidic (MF) channels based on shaping, bonding, and assembly of sucrose fibers. It is a simple, cleanroom-free, and environment-friendly method, ideal for rapid prototyping of lab-on-a-chip devices. Despite its simplicity, it can realize complex 3D MF channel architectures such as cylindrical tapers, internal loops, end-to-side junctions, tapered junctions, and stenosis. The last two will be of special use for realizing vaso-mimetic MF structures. It also enables molding with polymers incompatible with high-temperature processing.