Computational analysis of hemodynamics using a two-dimensional model in moyamoya disease Laboratory investigation
Computational analysis of hemodynamics using a two-dimensional model in moyamoya disease Laboratory investigation
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DOI：
10.3171/2009.10.peds09452
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发表时间：
2010-03-01
影响因子：
1.9
通讯作者：
Wang, Kyu-Chang
中科院分区：
文献类型：
--
作者：
Seol, Ho Jun;Shin, Duk Chul;Wang, Kyu-Chang
Object.烟雾病（MMD）的特征是双侧远端颈内动脉（ICA）内膜增厚和脑底许多侧支血管的发育。虽然MMD的病因和原因仅限于颅内主要血管尚不清楚，但血流动力学，如剪切应力，可能与其平滑肌细胞迁移有关。因此，本研究旨在确定局部血流动力学因素，这涉及到特定解剖部位的优势，如早期的伊卡远端和晚期的大脑后动脉（PCA）近端。作者使用远端伊卡和PCA的2D几何形状的计算模型模拟Willis环中的血流动力学。采用自动动力学增量非线性分析（ADINA）软件包，对这些动脉的血流进行了数值模拟。数值结果表明，伊卡区域的剪应力相对较低。切应力的分布与多发性骨髓瘤的发病部位有关。剪应力的降低可能会促进伊卡远端的狭窄，这是MMD的主要病理区域。(DOI：10.3171/2009.10.PEDS09452）
Object. Bilateral intimal thickening of the distal internal carotid arteries (ICAs) and the development of many collateral vessels in the base of the brain characterize moyamoya disease (MMD). Although the etiology of and the reason why MMD is limited to the major intracranial vessels remain unclear, flow dynamics,,such as shear stress, may be related to its smooth-muscle cell migration. Therefore, this study was performed to determine the local hemodynamic factor, which concerns the predominance of specific anatomical sites, Such as the distal ICA in the early stage and the proximal posterior cerebral artery (PCA) in the advanced stage of MMD.Methods. The authors Simulated the hemodynamics in the circle of Willis using computational models of 2D geometries of the distal ICA and PCA. A finite-clement commercial package, automatic dynamics incremental nonlinear analysis (ADINA), was used to simulate blood flow in these arteries.Results. Numerical results demonstrated that shear stress was relatively low at the ICA region. The distribution of shear stress was related to the predisposing area of MMD.Conclusions. Diminished shear stress may promote stenosis of the distal ICA, which is a major pathological region in MMD. (DOI: 10.3171/2009.10.PEDS09452)