Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
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DOI：
10.1002/eji.201444558
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发表时间：
2016-03
影响因子：
5.4
通讯作者：
Fitzgerald KA
中科院分区：
文献类型：
--
作者：
Elling R;Chan J;Fitzgerald KA
先天免疫系统代表感染期间的第一道防线，并且通过由种系编码的模式识别受体（PRR）检测保守的微生物产物而启动。通过PRR的传感诱导广泛的转录变化，引起强大的炎症反应。这些过程的严格调控依赖于多个调控检查点，包括非编码RNA种类，如microRNA。此外，长链非编码RNA（lncRNA）作为基因表达的重要调节因子，通过与DNA、RNA或蛋白质的多种相互作用发挥作用，最近已引起人们的注意。因此，这些RNA具有多种调节基因表达的机制。在这里，我们总结了这一快速发展和不断演变的领域的最新进展，突出了lncRNA对先天免疫细胞的发育和激活的贡献。此外，我们还讨论了全面研究候选非编码RNA基因座功能所需的实验方法。
The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by germline-encoded pattern recognition receptors (PRRs). Sensing through PRRs induces broad transcriptional changes that elicit powerful inflammatory responses. Tight regulation of these processes depends on multiple regulatory checkpoints including noncoding RNA species such as microRNAs. In addition, long noncoding RNAs (lncRNAs) have recently gained attention as important regulators of gene expression acting through versatile interactions with DNA, RNA, or proteins. As such, these RNAs have a multitude of mechanisms to modulate gene expression. Here, we summarize recent advances in this rapidly moving and evolving field, highlighting the contribution of lncRNAs to both the development and activation of innate immune cells. In addition, we discuss experimental approaches required to comprehensively investigate the function of a candidate noncoding RNA locus.