Effects of zinc acexamate on gastric mucosal resistance factors.
Effects of zinc acexamate on gastric mucosal resistance factors.
复制标题
醋氨酸锌对胃粘膜抵抗因子的影响。
DOI：
10.1016/0014-2999(85)90415-7
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发表时间：
1985
影响因子：
5
通讯作者：
J. Esplugues
中科院分区：
文献类型：
--
作者：
J. Esplugues;Oriol Bulbeena;G. Escolar;E. Martí‐Bonmatí;J. Esplugues
本文观察醋氨己酸锌对大鼠胃防御系统的影响。用醋氨己酸锌进行不同的预处理，可明显减少口服三种坏死剂（0.6 N HCl，25% NaCl，100%乙醇）引起的胃溃疡。这种细胞保护作用没有被先前的吲哚美辛治疗（口服30 mg/kg）所改变。醋氨己酸锌预处理还可以防止阿司匹林（40 mM）引起的胃粘膜屏障破坏，并增加胃腺和气管壁中的粘液产生。这些观察结果表明，锌盐的抗溃疡作用可能是增加胃粘膜防御系统的作用的结果，至少部分是这样。
The effects of zinc acexamate on gastric defensive systems were evaluated in the rat. Gastric ulcers induced by oral administration of three necrotic agents (0.6 N HCl, 25% NaCl, 100% ethanol) were markedly reduced by different pretreatments with zinc acexamate. This cytoprotective effect was not modified by previous treatment with indomethacin (30 mg/kg orally). Zinc acexamate pretreatment also prevents the disruption of the gastric mucosal barrier induced by aspirin (40 mM) and increases mucus production in the gastric glands and tracheal walls. These observations suggest that the antiulcer effects described for zinc salts could be the result, at least partly, of an action increasing gastric mucosal defensive systems.