Radiotracer Imaging of Atherosclerotic Plaque Biology
Radiotracer Imaging of Atherosclerotic Plaque Biology
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DOI：
10.1016/j.ccl.2008.12.006
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发表时间：
2009-05-01
影响因子：
2.4
通讯作者：
Rudd, James H. F.
中科院分区：
文献类型：
--
作者：
Elkhawad, Maysoon;Rudd, James H. F.
用于评估动脉粥样硬化斑块的传统成像方式集中于大小、位置和管腔侵犯的解剖特征。然而，识别有破裂风险并因此可能继续导致临床事件的斑块的能力仍然有限。通过标记示踪剂化合物，能够识别重要的细胞或分子过程中涉及斑块的脆弱性与放射性同位素，现在有可能非侵入性识别脆弱斑块。本文讨论了几种放射性示踪剂，可以报告高风险斑块的病理生理学。
Traditional imaging modalities used in the assessment of atherosclerotic plaque have focused on anatomic characteristics of size, location and luminal encroachment. The ability to identify plaques that are at risk for rupture, and thus may go on to cause clinical events, remains limited, however. By labeling tracer compounds capable of identifying important cellular or molecular processes involved in plaque vulnerability with radioactive isotopes, there is now potential for the noninvasive identification of vulnerable plaques. This article discusses several radiotracers; that can report on high-risk plaque pathophysiology.