The genomics of yeast responses to environmental stress and starvation.
The genomics of yeast responses to environmental stress and starvation.
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DOI：
10.1007/s10142-002-0058-2
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发表时间：
2002-09-01
影响因子：
2.9
通讯作者：
Werner-Washburne, Margaret
中科院分区：
文献类型：
--
作者：
Gasch, Audrey P;Werner-Washburne, Margaret
单细胞生物，如酵母，已经进化到能够在外部环境的持续波动中生存下来，方法是迅速调整它们的内部系统，以应对每个新环境的挑战。这种细胞适应的一个方面是基因组表达的重组，以适应在每种环境中生长所需的程序。基因组表达的重新编程可以通过DNA微阵列来揭示，DNA微阵列测量的是生物体基因组中几乎每一个基因的相对转录丰度。表征环境引发的基因表达变化提供了对每个基因何时、何地和如何表达的洞察，并提供了细胞对环境变化的生理反应的一瞥。这篇综述将集中在萌芽酵母的基因组表达对不同环境变化的反应，突出了从已发表的酵母基因组表达研究集合中出现的一些主题。这些研究的结果提供了关于酵母细胞如何感知和响应每个新环境的见解，并提出了这种有机体用来在应激环境变化中生存的机制。
Unicellular organisms such as yeast have evolved to survive constant fluctuations in their external surroundings by rapidly adapting their internal systems to meet the challenges of each new environment. One aspect of this cellular adaptation is the reorganization of genomic expression to the program required for growth in each environment. The reprogramming of genomic expression can be unveiled using DNA microarrays, which measure the relative transcript abundance of essentially every gene in an organism's genome. Characterizing environmentally triggered gene expression changes provides insights into when, where, and how each gene is expressed and offers a glimpse at the physiological response of the cells to changes in their surroundings. This review will focus on the genomic expression responses of the budding yeast Saccharomyces cerevisiae to diverse environmental changes, highlighting some of the themes that have emerged from the collection of published yeast genomic expression studies. The results of these studies present insights as to how yeast cells sense and respond to each new environment, and suggest mechanisms that this organism uses to survive stressful environmental changes.