Anterior Intraparietal Area: A Hub in the Observed Manipulative Action Network
Anterior Intraparietal Area: A Hub in the Observed Manipulative Action Network
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DOI：
10.1093/cercor/bhz011
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发表时间：
2019-04-01
期刊：
影响因子：
3.7
通讯作者：
Orban, Guy A.
中科院分区：
文献类型：
--
作者：
Lanzilotto, Marco;Ferroni, Carolina Giulia;Orban, Guy A.
关于观察到的操纵行为（OMA）的处理的现有知识（例如，抓握、拖拽或放下）仅限于抓握，并且潜在的神经回路仍然存在争议。在这里，我们解决了这些问题相结合的慢性神经元记录沿着前后范围的猴子的前顶内（AIP）区示踪剂注射到记录的网站。我们发现了强大的神经选择性7个不同的OMAs，特别是在AIP（pAIP）的后部，在那里它与电动机编码的抓地力类型和自己的手视觉反馈。这组功能特性似乎是特别接地pAIP与腹侧视觉流和前额叶皮层的颞区更强的直接连接，作为与skeletomotor相关的领域和背侧视觉流的区域表现出相反或没有rostrocaudal梯度的连接。颞叶和前额叶区域可以提供与操纵动作处理相关的视觉和上下文信息。这些结果修改了现有的模型的行动观察网络，这表明，pAIP构成了一个顶叶枢纽的OMA身份路由信息的网络的其他节点。
Current knowledge regarding the processing of observed manipulative actions (OMAs) (e.g., grasping, dragging, or dropping) is limited to grasping and underlying neural circuitry remains controversial. Here, we addressed these issues by combining chronic neuronal recordings along the anteroposterior extent of monkeys' anterior intraparietal (AIP) area with tracer injections into the recorded sites. We found robust neural selectivity for 7 distinct OMAs, particularly in the posterior part of AIP (pAIP), where it was associated with motor coding of grip type and own-hand visual feedback. This cluster of functional properties appears to be specifically grounded in stronger direct connections of pAIP with the temporal regions of the ventral visual stream and the prefrontal cortex, as connections with skeletomotor related areas and regions of the dorsal visual stream exhibited opposite or no rostrocaudal gradients. Temporal and prefrontal areas may provide visual and contextual information relevant for manipulative action processing. These results revise existing models of the action observation network, suggesting that pAIP constitutes a parietal hub for routing information about OMA identity to the other nodes of the network.