MAGNETIC-RESONANCE SIGNAL ABNORMALITIES IN ASYMPTOMATIC INDIVIDUALS - THEIR INCIDENCE AND FUNCTIONAL CORRELATES
MAGNETIC-RESONANCE SIGNAL ABNORMALITIES IN ASYMPTOMATIC INDIVIDUALS - THEIR INCIDENCE AND FUNCTIONAL CORRELATES
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DOI：
10.1159/000116401
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发表时间：
1989-05-01
影响因子：
2.4
通讯作者：
FAZEKAS, F
中科院分区：
文献类型：
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作者：
FAZEKAS, F
在87名无脑血管病志愿者（31-83岁）中评估了MR信号异常，并与脑血管危险因素、脑血流量和葡萄糖代谢相关。皮质下和深层白色物质的病变从40岁时的11%增加到70岁以上受试者的83%，并且在具有脑血管危险因素的个体中更常被检测到（p < 0.01）。它们与较低的慢房室血流相关（p < 0.05），但不影响邻近皮质的葡萄糖代谢。脑室周围信号变化也随年龄增加，但与危险因素或功能数据无关。
MR signal abnormalities were assessed in 87 symptom-free volunteers (31-83 years of age) and correlated with cerebrovascular risk factors, cerebral blood flow and glucose metabolism. Lesions in the subcortical and deep white matter increased from 11% in the 4th decade to 83% in subjects over 70 years of age, and were detected significantly more often in individuals with cerebrovascular risk factors (p < 0.01). They were associated with lower slow-compartmental flow (p < 0.05) but did not affect adjacent cortical glucose metabolism. Periventricular signal changes also increased with age but were unrelated to risk factors or functional data.