Reversible cardiomyopathy caused by administration of interferon α
Reversible cardiomyopathy caused by administration of interferon α
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DOI：
10.1038/ncpcardio0069
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Judge, DP
中科院分区：
文献类型：
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作者：
Khakoo, AY;Halushka, MK;Judge, DP
背景：一位心功能正常的56岁男性因恶性黑色素瘤接受干扰素α-2b治疗。开始治疗八个月后，他出现劳累和呼吸困难。两个月后，他因矫形呼吸、呼吸困难和咳嗽而入院治疗。体检结果与充血性心力衰竭相一致。实验室研究是值得注意的甲状腺功能减退症。超声心动图显示严重的整体左心功能不全。检查超声心动图、心电图、血清化学、冠状动脉造影术、右心和左心插管及心内膜活检。诊断干扰素α-2b诱导的心肌病。静脉注射多巴酚丁胺和多巴胺治疗心源性休克和停用干扰素α-2b。
Background A 56-year-old man with normal cardiac function received treatment with interferon alpha-2b for malignant melanoma. Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion. Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough. Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction.Investigations Echiocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy.Diagnosis Interferon alpha-2b-induced cardiomyopathy.Management Intravenous dobutamine and dopamine for cardiogenic shock and discontinuation of interferon alpha-2b.