Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.
Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.
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DOI：
10.1016/j.ejphar.2008.06.084
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发表时间：
2008-09
影响因子：
5
通讯作者：
A. Pawlyk;P. Alfinito;D. Deecher
中科院分区：
文献类型：
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作者：
A. Pawlyk;P. Alfinito;D. Deecher
雌激素治疗减少卵巢切除大鼠的活跃期快速眼动（REM）睡眠。本文通过分析17α-炔雌醇（17α-EE）对去卵巢大鼠快速眼动睡眠（REM）活动期的频谱特性、REM睡眠次数和持续时间的影响，进一步探讨了17α-EE对REM睡眠的影响。REM睡眠的最大抑制发生在17α-EE治疗的第4天，是由于回合长度减少，并伴有EEG θ功率降低。这些结果进一步阐明了17α-EE对REM睡眠的影响，并为雌激素改变睡眠-觉醒模式的机制提供了更多的理解。
Estrogen treatment decreases active phase rapid eye movement (REM) sleep in ovariectomized rats. Here we explored further the effect of 17α-ethinyl estradiol (17α-EE) on active phase REM sleep in ovariectomized rats by analyzing spectral properties and the number and length of REM sleep bouts. The greatest suppression of REM sleep occurred on day 4 of 17α-EE treatment, was due to decreases in bout length, and was accompanied by decreased EEG theta power. These results further elucidate 17α-EE's effects on REM sleep and provide greater understanding of the mechanisms by which estrogens alter sleep–wakefulness patterns.