Ischemic acute pancreatitis: clinical features of 11 patients and review of the literature
Ischemic acute pancreatitis: clinical features of 11 patients and review of the literature
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DOI：
10.1016/j.amjsurg.2008.04.011
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发表时间：
2009-04-01
影响因子：
3
通讯作者：
Werner, Jens
中科院分区：
文献类型：
--
作者：
Hackert, Thilo;Hartwig, Werner;Werner, Jens
背景：除了酒精和胆结石。胰腺缺血可引起急性胰腺炎（AP）。当无法确定其他原因时，应考虑该实体。本研究的目的是通过病理生理学来定义缺血性AP。方法：对11例不同病因的缺血性AP患者的病程、严重程度、预后以及诊断和治疗措施进行分析.结果：缺血性AP由出血和低血压（7例）或肠系膜大血管闭塞（4例）引起.保守治疗4例，手术治疗7例。7例患者在38天内死亡。结论：胰腺低灌注是AP的重要病因。疾病的严重程度范围从中度可逆变化到具有致死性结局的重度病程。缺血性AP的外科治疗适应症是更积极的诊断和保守的治疗程序类似于其他病因的AP。(C)2009 Elsevier Inc. All rights reserved.
BACKGROUND: Besides alcohol and gallstones. pancreatic ischemia can cause acute Pancreatitis (AP). This entity should be considered when no other reasons can be defined. The aim of the Current Study was to define ischemic AP with its pathophysiologic. radiologic, and clinical conditions.METHODS: Eleven patients with ischemic All of different origin were analyzed regarding course, severity, and outcome, as well as diagnostic and therapeutic measures.RESULTS: Ischemic AP was caused by hemorrhage and hypotension (7 patients) or mesenteric macrovessel occulsion (4 patients). Therapy was conservative (4 patients) or operative With hemostasis, necrosectomy, and drainage (7 patients). Seven patients died within 38 clays. and 4 patients recovered.CONCLUSION: Pancreatic hypoperfusion is an important etiology of AP. Severity of the disease ranges from moderate reversible changes to severe courses with fatal outcome. The indication for surgical intervention in ischemic AP is more aggressive diagnostic and conservative therapeutic procedures are similar to AP of other etiologies. (C) 2009 Elsevier Inc. All rights reserved.