Biomaterials that regulate growth factor activity via bioinspired interactions.
Biomaterials that regulate growth factor activity via bioinspired interactions.
复制标题
通过生物启发的相互作用调节生长因子活性的生物材料。
DOI：
10.1002/adfm.201002468
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发表时间：
2011-05-24
影响因子：
19
通讯作者：
Murphy, William L.
中科院分区：
文献类型：
--
作者：
Hudalla, Gregory A.;Murphy, William L.
生长因子活性通过与核心ECM生物分子（例如蛋白质和蛋白聚糖）的特异性非共价相互作用而定位于天然细胞外基质（ECM）内。最近，这些相互作用启发了我们和其他人开发合成生物材料，可以非共价调节生长因子的活性，用于组织工程应用。例如，用肝素糖胺聚糖共价或非共价修饰的生物材料可以增强生长因子释放策略。此外，最近的研究表明，肝素结合肽修饰的生物材料可以隔离细胞分泌的肝素蛋白聚糖，进而隔离生长因子和调节干细胞的行为。另一组研究表明，生长因子分子的模块化版本可以被设计成与天然和合成ECM的特定组分相互作用，包括胶原蛋白和羟基磷灰石。此外，GAG和其他天然聚电解质的逐层组装体通过特定的非共价相互作用将生长因子保留在细胞-材料界面处。本文将详细介绍各种bioinspired战略被用于非共价本地化的生长因子活性的生物材料，并将突出这些材料的功效，以促进组织再生的体内例子。
Growth factor activity is localized within the natural extracellular matrix (ECM) by specific non-covalent interactions with core ECM biomolecules, such as proteins and proteoglycans. Recently, these interactions have inspired us and others to develop synthetic biomaterials that can non-covalently regulate growth factor activity for tissue engineering applications. For example, biomaterials covalently or non-covalently modified with heparin glycosaminoglycans can augment growth factor release strategies. In addition, recent studies demonstrate that biomaterials modified with heparin-binding peptides can sequester cell-secreted heparin proteoglycans and, in turn, sequester growth factors and regulate stem cell behavior. Another set of studies show that modular versions of growth factor molecules can be designed to interact with specific components of natural and synthetic ECMs, including collagen and hydroxyapatite. In addition, layer-by-layer assemblies of GAGs and other natural polyelectrolytes retain growth factors at a cell-material interface via specific non-covalent interactions. This review will detail the various bioinspired strategies being used to non-covalently localize growth factor activity within biomaterials, and will highlight in vivo examples of the efficacy of these materials to promote tissue regeneration.
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影响因子：
6.4
作者：
Cross, SS;Yang, ZY;Holen, I
通讯作者：
Holen, I
DOI：
10.1073/pnas.0505047102
发表时间：
2005-10-04
影响因子：
11.1
作者：
D'Andrea, LD;Iaccarino, G;Pedone, C
通讯作者：
Pedone, C
影响因子：
14
作者：
Cai, SS;Liu, YC;Prestwich, GD
通讯作者：
Prestwich, GD
影响因子：
64.8
作者：
COLE, GJ;LOEWY, A;GLASER, L
通讯作者：
GLASER, L
影响因子：
14
作者：
Backer, Marina V.;Patel, Vimal;Backer, Joseph M.
通讯作者：
Backer, Joseph M.