The molecular dynamics of feline coronaviruses
The molecular dynamics of feline coronaviruses
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DOI：
10.1016/s0378-1135(99)00099-1
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发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Rottier, PJM
中科院分区：
文献类型：
--
作者：
Rottier, PJM
猫冠状病毒很普遍，而且有不同的味道。有两种主要的血清型，这两种病毒都出现在两种致病类型中，无毒的肠道病毒和通常致命的腹膜炎病毒，后者在朗姆酒中以‘湿’或渗出型或以‘干’或增殖型出现。本文对这些病毒的分子特征作了简要的概述。对病毒的遗传动力学给予了特别的关注，因为这些现在让我们开始了解不同表型的起源，特别是在持续感染期间毒力的起源。正如所讨论的，过去几年获得的令人惊讶的新见解要求对保护战略进行批判性的重新评估。(C)1999 Elsevier Science B.V.保留所有权利。
Feline coronaviruses are widespread and come in different flavors. There are two main serotypes both of which occur in two pathotypes, the avirulent enteric viruses and the virulent, usually fatal peritonitis viruses, the latter in rum occurring either in a 'wet' or exudative form or in a 'dry' or proliferative form. In this paper a concise overview is given of the molecular features of these viruses. Special attention is given to the genetic dynamics of the viruses as these now allow us to begin to understand the origin of the different phenotypes, in particular the genesis of virulence during persistent infection. As discussed, the surprising new insights obtained over the last few years call for a critical reevaluation of strategies for protection. (C) 1999 Elsevier Science B.V. All rights reserved.