Turning moss into algae Prenylation targets in Physcomitrella patens
Turning moss into algae Prenylation targets in Physcomitrella patens
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DOI：
10.4161/psb.29314
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发表时间：
2014-01-01
影响因子：
2.9
通讯作者：
Running, Mark P.
中科院分区：
文献类型：
--
作者：
Antimisiaris, Marika F.;Running, Mark P.
异戊二烯化是一系列脂质翻译后修饰，涉及植物发育的几个关键方面。我们最近敲除小立碗藓中的每个异戊二烯化亚基。与拟南芥一样，P. patens 中蛋白质法尼基转移酶和蛋白质香叶基香叶基转移酶的敲除不会导致致死；然而，对发展的影响是广泛的。特别是，敲除蛋白质香叶基香叶基转移酶会产生类似于藻类的小型单细胞植物。在这里，我们对 P. patens 中预测的香叶基香叶基转移酶靶蛋白进行了分析，并提请注意那些最有可能在敲除表型中发挥作用的蛋白。
Prenylation is a series of lipid posttranslational modifications that are involved in several key aspects of plant development. We recently knocked out every prenylation subunit in Physcomitrella patens. Like in Arabidopsis, knockout of protein farnesyltransferase and protein geranylgeranyltransferase in P. patens does not result in lethality; however, effects on development are extensive. In particular, the knockout of protein geranylgeranyltransferase results in small unicellular plants that resemble algae. Here we perform an analysis of predicted geranylgeranyltransferase target proteins in P. patens, and draw attention to those most likely to play a role in the knockout phenotype.