The phosphate clamp as recognition motif in platinum-DNA interactions
The phosphate clamp as recognition motif in platinum-DNA interactions
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DOI：
10.1016/j.ica.2016.04.052
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发表时间：
2016-10-01
影响因子：
2.8
通讯作者：
Farrell, Nicholas P.
中科院分区：
文献类型：
--
作者：
Komeda, Seiji;Qu, Yun;Farrell, Nicholas P.
本文综述了取代惰性多核铂配合物（PPC）通过磷酸钳与DNA结合的研究进展。磷酸钳是DNA与配体识别的一种离散模式，不同于经典的嵌入和小沟结合。本文重点比较了三核铂配合物与双核精胺配合物的结合和构象变化。质子化的精胺中心多胺-+ NH_2-（CH_2）（4）-N+ H_2-可与三核配合物的中心Pt（四胺）部分直接比较。证据的重要性表明，虽然小分子上的总电荷决定了结合亲和力，但从磷酸钳跨越的小沟的存在在构象变化和序列选择性中很重要。(C)2016由Elsevier B. V.出版
This review summarizes studies on substitution-inert polynuclear platinum complexes (PPCs) which bind to DNA through the phosphate clamp - a discrete mode of DNA-ligand recognition distinct from the canonical intercalation and minor-groove binding. Especially, this review concentrates on comparing the binding and conformational changes induced by trinuclear platinum complexes with dinuclear spermine-linked complexes. The protonated central polyamine-+NH2-(CH2)(4)-N+H2- of spermine allows direct comparison with the central Pt(tetraamine) moiety of the trinuclear complexes. The weight of the evidence suggests that while overall charge on the small molecule determines binding affinity, the presence of minor groove spanning from the phosphate clamp is important in conformational changes and in sequence selectivity. (C) 2016 Published by Elsevier B.V.