Post-transcriptional regulation of gene expression by Unr.
Post-transcriptional regulation of gene expression by Unr.
复制标题
DOI：
10.1042/bst20140271
复制
发表时间：
2015-06
影响因子：
3.9
通讯作者：
Swagat Ray;Pól Ó Catnaigh;Emma C. Anderson
中科院分区：
文献类型：
--
作者：
Swagat Ray;Pól Ó Catnaigh;Emma C. Anderson
Unr（N-ras上游）是一种真核RNA结合蛋白，在基因表达的转录后调控中具有许多作用。最初被鉴定为小核糖核酸病毒翻译内部起始的激活剂，此后已显示其作为细胞翻译的激活剂和抑制剂以及作为mRNA稳定性的正和负调节剂，调节细胞过程如有丝分裂和凋亡。Unr的不同转录后功能取决于其mRNA和蛋白质伴侣的身份，并可随细胞类型和细胞条件的变化而变化。最近对RNA-蛋白质相互作用的高通量分析表明，Unr与细胞mRNA的一个大子集结合，这表明Unr可能在细胞信号的翻译反应中发挥比以前认为的更广泛的作用。
Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can vary with cell type and changing cellular conditions. Recent high-throughput analyses of RNA-protein interactions indicate that Unr binds to a large subset of cellular mRNAs, suggesting that Unr may play a wider role in translational responses to cellular signals than previously thought.