TENSILE PROPERTIES OF HUMAN KNEE-JOINT CARTILAGE .2. CORRELATIONS BETWEEN WEIGHT BEARING AND TISSUE PATHOLOGY AND THE KINETICS OF SWELLING
TENSILE PROPERTIES OF HUMAN KNEE-JOINT CARTILAGE .2. CORRELATIONS BETWEEN WEIGHT BEARING AND TISSUE PATHOLOGY AND THE KINETICS OF SWELLING
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DOI：
10.1002/jor.1100050204
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发表时间：
1987-01-01
影响因子：
2.8
通讯作者：
HOWELL, DS
中科院分区：
文献类型：
--
作者：
AKIZUKI, S;MOW, VC;HOWELL, DS
使用我们的等长拉伸仪（ITA）测量了正常、原纤化和骨关节炎（OA）（从全膝关节置换术中取出）人膝关节软骨的非平衡或动力学肿胀行为。我们发现，人类膝关节软骨肿胀的方式存在较大的局部变化，包括各向异性效应，不均匀性，以及对局部生化成分和病理条件的依赖。ITA提供了三个方便的生物力学参数-峰值应力（σ p）、应力松弛（σ R）和扩散系数（D）-以量化溶胀的动力学。我们使用这些参数来量化和区分正常，原纤化和骨关节炎软骨的动力学肿胀行为，以及高和低负重区软骨的肿胀行为。此外，这些动力学溶胀参数相关性很好，虽然不同程度上，与这样的生化措施，胶原蛋白/蛋白多糖的比例，氨基己糖含量/湿重，和羟脯氨酸含量/干重，提供重要的洞察过程中涉及的机制和过程的肿胀。因此，软骨的动力学膨胀行为应被用来提供平衡膨胀研究所不能提供的重要信息。
The nonequilibrium or kinetic swelling behavior of normal, fibrillated, and osteoarthritic (OA) (removed from total knee joint replacements) human knee joint cartilage has been measured using our isometric tensile apparatus (ITA). We found that large local variations exist in the manner with which human knee joint cartilage swells, including anisotropic effects, inhomogeneities, and dependence on local biochemical composition and pathological condition. The ITA provides three convenient biomechanical parameters - peak stress (.sigma.p), stress relaxation (.sigma.R), and diffusion coefficient (D) - to quantify the kinetics of swelling. We used these parameters to quantify and differentiate the kinetic swelling behavior of normal, fibrillated, and osteoarthritic cartilage, as well as the swelling behavior of cartilage from high and low weight-bearing areas. Also, these kinetic swelling parameters correlated very well, though by varying degrees, with such biochemical measures as collagen/proteoglycan ratio, hexosamine content/wet weight, and hydroxyproline content/dry weight, providing important insight into the mechanisms and processes involved during the course of swelling. Hence, the kinetic swelling behavior of cartilage should be used ot provide important information not obtainable from equilibrium swelling studies.