Inhibitory repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex modulates early affective processing
Inhibitory repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex modulates early affective processing
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DOI：
10.1016/j.neuroimage.2014.07.003
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发表时间：
2014-11
期刊：
影响因子：
5.7
通讯作者：
P. Zwanzger;C. Steinberg;M. Rehbein;Ann-Kathrin Bröckelmann;C. Dobel;M. Zavorotnyy;K. Domschke;M. Junghöfer
中科院分区：
文献类型：
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作者：
P. Zwanzger;C. Steinberg;M. Rehbein;Ann-Kathrin Bröckelmann;C. Dobel;M. Zavorotnyy;K. Domschke;M. Junghöfer
背外侧前额叶皮层（dlPFC）经常被认为是情绪刺激评估和调节的关键调节器。因此，在临床试验中，它是重复经颅磁刺激（rTMS）等非侵入性脑刺激最常见的目标区域之一。尽管有各种令人鼓舞的报告证明 rTMS 对焦虑症有益，但探索潜在神经机制的心理生理学研究却很少。在这里，我们研究了当应用于右侧 dlPFC 时，抑制性 rTMS 如何影响早期情感处理。在 rTMS 或假刺激之前和之后，受试者看到带有恐惧或中性表情的面孔，同时记录全头脑磁图 (MEG)。由于右侧 dlPFC 功能受损，双侧顶叶、颞叶和枕叶区域的视觉处理在刺激开始后 90 毫秒左右开始增强。此外，在 110 至 170 毫秒的时间间隔内，右侧 TPJ 区域的恐惧特异性激活增加。这些神经生理学影响反映在面部表情识别任务中对恐惧的反应时间减慢，但对于中性面孔则不然，而在性别歧视控制任务中则没有这种影响。我们的研究证实了 dlPFC 在调节早期情绪注意力方面的具体而重要的作用，并鼓励未来的临床研究使用微创方法，如经颅磁 (TMS) 或直流电刺激 (tDCS)。
The dorsolateral prefrontal cortex (dlPFC) has often been suggested as a key modulator of emotional stimulus appraisal and regulation. Therefore, in clinical trials, it is one of the most frequently targeted regions for non-invasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). In spite of various encouraging reports that demonstrate beneficial effects of rTMS in anxiety disorders, psychophysiological studies exploring the underlying neural mechanisms are sparse. Here we investigated how inhibitory rTMS influences early affective processing when applied over the right dlPFC. Before and after rTMS or sham stimulation, subjects viewed faces with fearful or neutral expressions while whole-head magnetoencephalography (MEG) was recorded. Due to the disrupted functioning of the right dlPFC, visual processing in bilateral parietal, temporal, and occipital areas was amplified starting at around 90 ms after stimulus onset. Moreover, increased fear-specific activation was found in the right TPJ area in a time-interval between 110 and 170 ms. These neurophysiological effects were reflected in slowed reaction times for fearful, but not for neutral faces in a facial expression identification task while there was no such effect on a gender discrimination control task. Our study confirms the specific and important role of the dlPFC in regulation of early emotional attention and encourages future clinical research to use minimal invasive methods such as transcranial magnetic (TMS) or direct current stimulation (tDCS).