Hydroxyanthraquinones from Abrus cantoniensis
Hydroxyanthraquinones from Abrus cantoniensis
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DOI：
10.1055/s-2007-971214
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发表时间：
1982-11
期刊：
影响因子：
2.7
通讯作者：
S. Wong;T. Chiang;Hson-Mou Chang
中科院分区：
文献类型：
--
作者：
S. Wong;T. Chiang;Hson-Mou Chang
在前人的文章中，我们报道了从广东Abrus cantoniensis HANCE[1]的根中分离和鉴定了四种皂苷类化合物，即广东皂苷醇、苦参醇、大豆皂苷B和大豆皂苷a。该通讯涉及从同一植物中分离大黄酚（1,8 -二羟基-3-甲氧基-6-甲基-蒽醌）和物理（1,8 -二羟基-3-甲氧基-6-甲基-蒽醌）[21]。羟基蒽醌类化合物及其苷类化合物以前尚未从任何属艾草属的物种中分离出来。介绍了植物原料、提取、丁醇提取物的水解和苷元的初步分离。蒽醌类化合物由稀KOH溶液提取的弱酸性苷元部分得到。粗酸性苷元（从2kg植物材料中提取1.5 g）在硅胶（Merck, Art. 9385）上进行色谱分析，用石油醚和乙酸乙酯（4:6）洗脱。早期馏分产大黄酚，尾部馏分含大黄酚和物理离子的混合物。后者采用制备层析（0.25 mm硅胶板，开发溶剂体系，pet-et-her: EtOAc= 3:7）进一步分离。
In a previous paper, we reported the isolation and cha-racterization of four sapogenols, cantoniensistriol, sopho-radiol, soyasapogenols B and A from the roots of Abrus cantoniensis HANCE [1]. This communication deals with the isolation of chrysophanol (1, 8-dihydroxy-3-methyl-anthraquinone) and physcion (1, 8-dihydroxy-3-methoxy-6-methyl-anthraquinone) from the same plant [21. Hydroxyan-thraquin ones and their glycosides have previously not been isolated from any species that belongs to Abrus genus. The plant material, extraction, hydrolysis of the butanol extract and the preliminary separation of the aglycones were described in [1]. The anthraquinones were derived from the weak acidic aglycone portion extracted by dilute KOH solution. The crude acidic aglycones (1.5 g from 2kg plant material) were chromatographed on silica gel (Merck, Art. 9385) and eluted with petroleum ether and ethyl acetate (4: 6). Early fractions yielded chrysophanol and the tail fractions contained a mixture of chrysophanol and phys-cion. The latter was further separated by preparative TLC (0.25 mm Si-gel plate, developing solvent system, pet-et-her: EtOAc= 3: 7).