mTOR - beyond transplantation
mTOR - beyond transplantation
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DOI：
10.1016/j.coph.2005.03.004
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发表时间：
2005-08-01
影响因子：
4
通讯作者：
Nickerson-Nutter, CL
中科院分区：
文献类型：
--
作者：
Young, DA;Nickerson-Nutter, CL
mTOR激酶在许多细胞类型的活化中起核心作用，并且用雷帕霉素阻断mTOR功能导致细胞周期停滞在G1期。最近，已经在mTOR通路中鉴定了几种额外的分子，为干扰细胞活化和开发新型治疗剂提供了进一步的机会。在某些条件下和特定的细胞类型中，激活可以独立于mTOR并且在雷帕霉素存在下发生。在适当的环境中选择性抑制细胞活化可能被证明对几种自身免疫性或炎症性疾病有益。
mTOR kinase plays a central role in the activation of many cell types, and blocking mTOR function with rapamycin results in arrest of the cell cycle at the G1 phase. Recently, several additional molecules have been identified in the mTOR pathway, providing further opportunities to interfere with cell activation and develop novel therapeutic agents. Under certain conditions and in specific cell types, activation can occur independently of mTOR and in the presence of rapamycin. Selective inhibition of cell activation in the appropriate setting might prove to be beneficial for several autoimmune or inflammatory diseases.